Ximelagatran
CAS 192939-46-1 MFCD05861056
化学结构图
SMILES: CCOC(=O)CN[C@H](C1CCCCC1)C(=O)N1CC[C@H]1C(=O)NCC1C=CC(=CC=1)C(=N)NO
化学属性
| Mol. Formula | C24H35N5O5 |
|---|---|
| Mol. Weight | 473.57 |
别名和识别编码
| Chemical Name | Ximelagatran |
|---|---|
| CAS Number | 192939-46-1 |
| Synonym | N-[(1R)-1-Cyclohexyl-2-[(2S)-2-[[[[4-[(hydroxyamino)iminomethyl]phenyl]methyl]amino]carbonyl]-1-azetidinyl]-2-oxoethyl]glycine Ethyl Ester Exanta H 376/95 |
| Chemical Name Translation |
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分类
- Aromatics
- Chiral Reagents
- Pharmaceuticals
- Intermediates & Fine Chemicals,
产品应用
- An orally active direct thrombin inhibitor; prodrug of Melagatran. Antithrombotic.
相关文献及参考
- [2]. Gao JH, et al. Effects of different anticoagulant drugs on the prevention of complications in patients after arthroplasty: A network meta-analysis. Medicine (Baltimore). 2017 Oct;96(40):e8059.
- [3]. Francis CW, et al. Comparison of ximelagatran with warfarin for the prevention of venous thromboembolism after total knee replacement. N Engl J Med. 2003 Oct 30;349(18):1703-12.
- Boos, C.J., et al.: Eur. J. Int. Med., 16, 267 (2005),
- Kalus, J.S., et al.: Expert Opin. Invest. Drugs, 13, 465 (2004),
- Owens, P.K., et al.: J. Pharm. Biomed. Anal., 27, 587 (2002),
- [1]. Colwell CW Jr, et al. Comparison of ximelagatran, an oral direct thrombin inhibitor, with enoxaparin for the preventi
- [1]. Colwell CW Jr, et al. Comparison of ximelagatran, an oral direct thrombin inhibitor, with enoxaparin for the prevention of venous thromboembolism following total hip replacement. A randomized, double-blind study. J Thromb Haemost. 2003 Oct;1(10):2119-30.
