N,N,N,N-Tetramethyl-S-(1-Oxido-2-Pyridyl)Thiuronium Hexafluorophosphate N,N,N,N-四甲基-S-(1-氧代-2-吡啶基)硫脲六氟磷酸盐(HOTT)

CAS 212333-72-7 MFCD05865266

化学结构图

212333-72-7
SMILES: CN(C)C(=[S+]C1=CC=CC=[N+]1[O-])N(C)C.F[P-](F)(F)(F)(F)F

化学属性

Mol. FormulaC10H16F6N3OPS
Mol. Weight371
Melting Point120-125
TSCANo

别名和识别编码

Chemical NameN,N,N,N-Tetramethyl-S-(1-Oxido-2-Pyridyl)Thiuronium Hexafluorophosphate
Synonym N,N,N′,N′-四甲基-S-(1-氧代-2-吡啶基)硫脲六氟磷酸盐 N,N,N',N'-Tetramethyl-S-(1-oxido-2-pyridyl)thiuronium hexafluorophosphate N,N,N′,N′-四甲基-S-(1-氧代-2-吡啶基)硫脲六氟磷酸盐 S-(2-吡啶基)-N,N,N′,N′-四甲基硫脲 N-氧化物六氟磷酸盐
MDL NumberMFCD05865266
PubChem Substance ID135726923
CAS Number212333-72-7
Reaxys-RN8175482
Chemical Name TranslationN,N,N,N-四甲基-S-(1-氧代-2-吡啶基)硫脲六氟磷酸盐(HOTT)
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分类

  • {SA} Chemical Biology, Chemical Synthesis, Coupling, Peptide Chemistry, Peptide Coupling, Phosphonium/Uronium/Formamidinium, Synthetic Reagents
  • {SNA} Chemical Biology, Chemical Synthesis, Coupling, Peptide Chemistry, Peptide Coupling, Phosphonium/Uronium/Formamidinium, Synthetic Reagents

相关文献及参考

  • 1. Bryan Knuckley, et al Biochemistry 49 , 4852-4863, (2010) 摘要
  • 2. Erwin Hohn, et al Eur. J. Org. Chem. 22 , 3765-3782, (2009)
  • 3. Erwin Hohn and Joerg Pietruszka Adv. Synth. Catal. 346 , 863-866, (2004)
  • 4. Philip Garner, et al Tetrahedron Asymmetry 14 , 2883-2887, (2003)
  • 5. Fernando Albericio, et al Tetrahedron 57 , 9607-9613, (2001)
  • 6. M. A. Bailen, et al Tetrahedron Lett. 41 , 9809-9813, (2000)
  • 7. M.A. Bailen et al. J. Org. Chem. 64 , 8936, (1999) 摘要
  • 8. F. Albericio et al. Tetrahedron 57 , 9607, (2001)

安全信息

WGK Germany3
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Storage condition Moisture Sensitive <;0 <0°C
Signal word
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
Precautionary statements
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
  • P302+P352+P332+P313+P362+P364
  • P305+P351+P338+P337+P313
Safety Statements
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置;
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S37 Wear suitable gloves 戴适当手套;
Risk Statements
GHS Symbol

系列性分类


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