Reversine 逆转素
CAS 656820-32-5 MFCD07784513
化学结构图
SMILES: c1nc2nc(Nc3ccc(N4CCOCC4)cc3)nc(NC3CCCCC3)c2[nH]1
化学属性
| Mol. Formula | C21H27N7O |
|---|---|
| Mol. Weight | 393.49 |
| Appearance | white solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name | Reversine |
|---|---|
| Synonym | 2-(4-Morpholinoanilino)-6-cyclohexylaminopurine Reversine Reversine. |
| MDL Number | MFCD07784513 |
| PubChem Substance ID | 24724590 |
| CAS Number | 656820-32-5 |
| Chemical Name Translation | 逆转素 |
| Formula | C21H27N7O |
| IUPAC Name | N6-cyclohexyl-N2-(4-morpholinophenyl)-7H-purine-2,6-diamine |
| InChIKey | ZFLJHSQHILSNCM-UHFFFAOYSA-N |
| InChI | InChI=1S/C21H27N7O/c1-2-4-15(5-3-1)24-20-18-19(23-14-22-18)26-21(27-20)25-16-6-8-17(9-7-16)28-10-12-29-13-11-28/h6-9,14-15H,1-5,10-13H2,(H3,22,23,24,25,26,27) |
| Canonical SMILES | C12=NC(NC3=CC=C(N4CCOCC4)C=C3)=NC(NC5CCCCC5)=C1NC=N2 |
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分类
- {SNA} Adenosines/P2 Nucleotide Receptors (Purinergics), Antagonists, Bioactive Small Molecule Alphabetical Index, Neuroscience, Neurotransmission, Neurotransmitters, R, Small Molecules for Stem Cell Biology, 干细胞生物学, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
- {SNA} Adenosines/P2 Nucleotide Receptors (Purinergics), Antagonists, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Neuroscience, Neurotransmission, Neurotransmitters, R, Small Molecules for Stem Cell Biology, Stem Cell Biology
产品应用
- Reversine is a small molecule developed by the group of Peter G. Schultz, used for stem cell dedifferentiation. Reversine is also a novel Aurora kinases inhibitor that inhibits colony formation of human acute myeloid leukemia cells. Reversine inhibits the phosphorylation of histone H3, a direct downstream target of Aurora kinases. Similarly to the Aurora kinase inhibitor VX-680, reversine inhibited colony formation of leukemic cells from patients with acute myeloid leukemia but was significantly less toxic than VX-680 on cells from healthy donors.
安全信息
GHS Symbol
- H302 Harmful if swallowed 吞食有害
- R22 Harmful if swallowed 吞咽有害
