Cefoperazone Sodium 头孢哌酮钠

CAS 62893-20-3 MFCD07793331

化学结构图

62893-20-3
SMILES: [Na+].CN1N=NN=C1SCC1CS[C@@H]2[C@H](NC(=O)[C@H](NC(=O)N3CCN(CC)C(=O)C3=O)C3C=CC(O)=CC=3)C(=O)N2C=1C([O-])=O

化学属性

Mol. FormulaC25
Mol. Weight668
Melting Point200-202

别名和识别编码

Chemical NameCefoperazone Sodium
MDL NumberMFCD07793331
Beilstein Registry Number4902135
EC Number263-751-5
PubChem Substance ID24892686
Synonym T-1551 Sodium cefoperazone Cefoperazone sodium 头孢哌酮 钠盐
Chemical Name Translation头孢哌酮钠
Wiswesser Line NotationT46 ANV ES GUTJ HVO CMVYR DQ&MV- AT6NVVNTJ D2& G1S-ET5NNNNJ A1 &-NA-
CAS Number62893-20-3
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分类

  • {SNA} A - K, Antibacterial, Antibiotics A to Z, Antibiotics A-F, Chemical Structure Class, Interferes with Cell Wall Synthesis, Mechanism of Action, Penicillins and Cephalosporins (beta-Lactams), Spectrum of Activity, 抗生素, 生化试剂
  • {SNA} A - K, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics A-F, Chemical Structure Class, Interferes with Cell Wall Synthesis, Mechanism of Action, Penicillins and Cephalosporins (beta-Lactams), Spectrum of Activity

安全信息

WGK Germany2
RTECSXI0374000
GHS Symbol
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P342+P311
Hazard statements
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled 吸入可能导致过敏或哮喘症状或呼吸困难
Signal word Danger
Hazard Codes Xn
Safety Statements
  • S22 Do not breathe dust 不要吸入粉尘;
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
Risk Statements
  • R42/43
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >12 gm/kg
TOXIC EFFECTS :
   Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
   NKRZAZ Chemotherapy (Tokyo).  (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
   Shinagawa-Ku, Tokyo 141, Japan)  V.1-    1953- Volume(issue)/page/year:
   28(Suppl 6),179,1980

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 4260 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - acute pulmonary edema
REFERENCE :
   NKRZAZ Chemotherapy (Tokyo).  (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
   Shinagawa-Ku, Tokyo 141, Japan)  V.1-    1953- Volume(issue)/page/year:
   28(Suppl 6)

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 13 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: -,663,1995

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >15 gm/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Gastrointestinal - hypermotility, diarrhea
   Skin and Appendages - hair
REFERENCE :
   NKRZAZ Chemotherapy (Tokyo).  (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
   Shinagawa-Ku, Tokyo 141, Japan)  V.1-    1953- Volume(iss

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Human - man
DO

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 2750 mg/kg
SEX/DURATION            : female 7-17 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Maternal Effects - other effects
REFERENCE :
   NKRZAZ Chemotherapy (Tokyo).  (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
   Shinagawa-Ku, Tokyo 141, Japan)  V.1-    1953- Volume(issue)/page/year:
   28(Suppl 6),268,1980

系列性分类


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