(-)-Blebbistatin 细胞抑制剂(-)-BLEBBISTATIN
CAS 856925-71-8 MFCD08460907
化学结构图
SMILES: CC1C=C2C(=O)[C@]3(O)CCN(C3=NC2=CC=1)C1C=CC=CC=1
化学属性
| Mol. Formula | C18H16N2O2 |
|---|---|
| Mol. Weight | 292.33 |
别名和识别编码
| Chemical Name | (-)-Blebbistatin |
|---|---|
| CAS Number | 856925-71-8 |
| Synonym | (-)-1-Phenyl-1,2,3,4-tetrahydro-4-hydroxypyrrolo[2,3-b]-7-methylquinolin-4-one (-)-Blebbistatin (3aS)-1,2,3,3a-Tetrahydro-3a-hydroxy-6-methyl-1-phenyl-4H-pyrrolo[2,3-b]quinolin-4-one 1-Phenyl-1,2,3,4-tetrahydro-4-hydroxypyrrolo[2.3-b]-7-methylquinolin-4-one |
| MDL Number | MFCD08460907 |
| PubChem Substance ID | 329773119 |
| Chemical Name Translation | 细胞抑制剂(-)-BLEBBISTATIN |
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分类
- {SNA} Actin Inhibitors and Probes, Apoptosis and Cell Cycle, B, Bioactive Small Molecule Alphabetical Index, Cell Cycle Proteins, Antibodies and Reagents, Cell Cycle Regulators, Cytoskeleton and Extracellular Matrix, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
- Inhibitors
- Chiral Reagents
- Pharmaceuticals
- {SNA} Actin Inhibitors and Probes, Apoptosis and Cell Cycle, B, Bioactive Small Molecules, Cell Biology, Cell Cycle Proteins and Antibodies, Cell Cycle Regulators, Cell Signaling and Neuroscience, Cytoskeleton and Extracellular Matrix
- Intermediates & Fine Chemicals,
产品应用
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相关文献及参考
- [2]. Ponsaerts R, et al. The myosin II ATPase inhibitor blebbistatin prevents thrombin-induced inhibition of intercellularcalcium wave propagation in corneal endothelial cells. Invest Ophthalmol Vis Sci. 2008 Nov;49(11):4816-27.
- Duxbury, M.S., et al.: Biochem. Biophys. Res. Commun., 313, 992 (2004),
- Straight, A.F., et al.: Science, 299, 1743 (2003),
- [1]. Cristina Lucas‐Lopez, et al. Absolute Stereochemical Assignment and Fluorescence Tuning of the Small Molecule Tool, (–)‐Blebbistatin.
- [1]. Cristina Lucas‐Lopez, et al. Absolute Stereochemical Assignment and Fluorescence Tuning of the Small Molecule Tool, (–)‐Blebbistatin.
- [2]. Ponsaerts R, et al. The myosin II ATPase inhibitor blebbistatin prevents thrombin-induced inhibition of intercellularcalcium wave propagation in corneal endothelial cells. Invest Ophthalmol Vis Sci. 2008 Nov;49(11):4816-27.
安全信息
GHS Symbol
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P305+P351+P338
- H332 Harmful if inhaled 吸入有害
- H315 Causes skin irritation 会刺激皮肤
- H317 May cause an allergic skin reaction 可能导致皮肤过敏
- H302 Harmful if swallowed 吞食有害
- H312 Harmful in contact with skin 皮肤接触有害
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- H319 Causes serious eye irritation 严重刺激眼睛
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
- R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
