3-(6-Methylpyridin-2-Yl)-N-Phenyl-4-(Quinolin-4-Yl)-1H-Pyrazole-1-Carbothioamide 3-(6-甲基吡啶-2-基)-N-苯基-4-(喹啉-4-基)-1H-吡唑-1-硫代甲酰胺
CAS 909910-43-6 MFCD08705403
化学结构图
SMILES: Cc1cccc(-c2nn(C(=S)Nc3ccccc3)cc2-c2ccnc3ccccc23)n1
化学属性
| Mol. Formula | C25H19N5S |
|---|---|
| Mol. Weight | 421.52 |
| Appearance | white solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name | 3-(6-Methylpyridin-2-Yl)-N-Phenyl-4-(Quinolin-4-Yl)-1H-Pyrazole-1-Carbothioamide |
|---|---|
| Synonym | 3-(6-Methylpyridin-2-yl)-1-phenylthiocarbamoyl-4-quinolin-4-ylpyrazole A8301; A 8301; A-8301 |
| MDL Number | MFCD08705403 |
| PubChem Substance ID | 24890977 |
| Chemical Name Translation | 3-(6-甲基吡啶-2-基)-N-苯基-4-(喹啉-4-基)-1H-吡唑-1-硫代甲酰胺 |
| Formula | C25H19N5S |
| IUPAC Name | 3-(6-methylpyridin-2-yl)-N-phenyl-4-(quinolin-4-yl)-1H-pyrazole-1-carbothioamide |
| InChIKey | HIJMSZGHKQPPJS-UHFFFAOYSA-N |
| InChI | InChI=1S/C25H19N5S/c1-17-8-7-13-23(27-17)24-21(19-14-15-26-22-12-6-5-11-20(19)22)16-30(29-24)25(31)28-18-9-3-2-4-10-18/h2-16H,1H3,(H,28,31) |
| Canonical SMILES | S=C(N1N=C(C2=NC(C)=CC=C2)C(C3=CC=NC4=CC=CC=C34)=C1)NC5=CC=CC=C5 |
信息真实价格透明
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信息真实价格透明
资金保障
专业采购外包团队在线服务
品牌质保精细包装
现货库存
一流品牌服务
产品应用
- A-83-01 is an ALK inhibibitor. It was found that A-83-01 inhibited the transcriptional activity induced by TGF-beta type I receptor ALK-5 and that by activin type IB receptor ALK-4 and nodal type I receptor ALK-7, the kinase domains of which are structurally highly related to those of ALK-5. A-83-01 was found to be more potent in the inhibition of ALK5 than a previously described ALK-5 inhibitor, SB-431542, and also to prevent phosphorylation of Smad2/3 and the growth inhibition induced by TGF-beta. A-83-01 inhibited the epithelial-to-mesenchymal transition induced by TGF-beta, suggesting that A-83-01 and related molecules may be useful for preventing the progression of advanced cancers.
安全信息
GHS Symbol
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P305+P351+P338
- H413 Maycauselonglastingharmfuleffectstoaquaticlife 可能对水生生物造成长期持续有害影响。
- H315 Causes skin irritation 会刺激皮肤
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- H302 Harmful if swallowed 吞食有害
- H319 Causes serious eye irritation 严重刺激眼睛
