(1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12-Tetramethyl-3-((E)-1-(2-Methylthiazol-4-Yl)Prop-1-En-2-Yl)-4,17-Dioxabicyclo[14.1.0]Heptadecane-5,9-Dione (1S,3S,7S,10R,11S,12S,16R)-7,11-二羟基-8,8,10,12-四甲基-3-((E)-1-(2-甲基噻唑-4-基)丙-1-烯-2-基)-4,17-二氧杂双环[14.1.0]十七烷-5,9-二酮
CAS 152044-53-6 MFCD09038683
化学结构图
SMILES: CC1=NC=C(/C=C(\C)/[C@@H]2C[C@@H]3O[C@@H]3CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O2)S1
化学属性
| Mol. Formula | C26H39NO6S |
|---|---|
| Mol. Weight | 493.66 |
别名和识别编码
| Chemical Name | (1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12-Tetramethyl-3-((E)-1-(2-Methylthiazol-4-Yl)Prop-1-En-2-Yl)-4,17-Dioxabicyclo[14.1.0]Heptadecane-5,9-Dione |
|---|---|
| CAS Number | 152044-53-6 |
| Synonym | (1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12-tetramethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione (-)-Epothilone A Epothilone A |
| Chemical Name Translation | (1S,3S,7S,10R,11S,12S,16R)-7,11-二羟基-8,8,10,12-四甲基-3-((E)-1-(2-甲基噻唑-4-基)丙-1-烯-2-基)-4,17-二氧杂双环[14.1.0]十七烷-5,9-二酮 |
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分类
- Chiral Reagents
- Inhibitors
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Sulfur & Selenium Compounds
产品应用
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相关文献及参考
- [2]. Cheng KL, et al. Novel microtubule-targeting agents - the epothilones. Biologics. 2008 Dec;2(4):789-811.
- Bollag, D.M., et al.: Cancer. Res., 55, 2325 (1995),
- Hardt, I.H., et al.: J. Nat. Prod., 64, 847 (2001),
- [1]. Kowalski RJ, et al. Activities of the microtubule-stabilizing agents epothilones A and B with purified tubulin and in cells resistant to paclitaxel (Taxol(R)). J Biol Chem. 1997 Jan 24;272(4):2534-41.
- [1]. Kowalski RJ, et al. Activities of the microtubule-stabilizing agents epothilones A and B with purified tubulin and in cells resistant to paclitaxel (Taxol(R)). J Biol Chem. 1997 Jan 24;272(4):2534-41.
- [2]. Cheng KL, et al. Novel microtubule-targeting agents - the epothilones. Biologics. 2008 Dec;2(4):789-811.
