Acetylsalicylic Acid 乙酰水杨酸

CAS 50-78-2 MFCD00002430

化学结构图

50-78-2
SMILES: CC(=O)Oc1ccccc1C(=O)O

化学属性

Mol. FormulaC9H8O4
Mol. Weight180.16
Melting Point134-136 °C
Density1.35
Flash Point250°(482°F)
TSCAYes
SolubilitySoluble in 100% ethanol (80mg/ml), DMSO (41mg/ml) or dimethyl formamide (30mg/ml); slightly soluble in PBS, pH 7.2 (2.7mg/ml).
Stability对湿度敏感
Appearance 本品为白色结晶,m.p.138~140℃,不溶于水,溶于醇、醚等。 crystalline
Boiling Point272.96 °C at 760 mmHg

别名和识别编码

Chemical NameAcetylsalicylic Acid
Synonym Aspirin {LY} Aspirin {} {LY} Aspirin {} {} {LY} Aspirin {} {} {} {LY} Aspirin {} {} {} {} {LY} Aspirin {} {} {} {} {} {LY} Aspirin {} {} {} {} {} {} {LY} Aspirin {} {} {} {} {} {} {} {LY} Aspirin {} {} {} {} {} {} {} {} {LY} Aspirin {} {} {} {} {} {} {} {} {} {LY} Aspirin {} {} {} {} {} {} {} {} {} {} {LY} Aspirin {} {} {} {} {} {} {} {} {} {} {} {LY} Aspirin {} {} {} {} {} {} {} {} {} {} {} {} {LY} Aspirin {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Aspirin {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Aspirin {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Aspirin {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Aspirin {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Aspirin {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Aspirin
CAS Number50-78-2
EC Number200-064-1
Beilstein Registry Number779271
MDL NumberMFCD00002430
Reaxys-RN779271
Merck Number851
PubChem Substance ID2244
Chemical Name Translation乙酰水杨酸
Wiswesser Line NotationQVR BOV1
LabNetwork Molecule IDLN00223310
InChIInChI=1S/C9H8O4/c1-6(10)13-8-5-3-2-4-7(8)9(11)12/h2-5H,1H3,(H,11,12)
Canonical SMILESOC(C1=C(OC(C)=O)C=CC=C1)=O
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分类

  • {SNA} A to C, Application Index, Arachidonic Acid Cascade, Cell Signaling Enzymes, Chemopreventive Agents, Core Bioreagents, Cyclooxygenase, Cyclooxygenase (COX) Enzymes, Cyclooxygenase Inhibitors, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Lipids in Cell Signaling,
  • {SNA} A to C,
  • {SNA} Acetylsal

产品应用

  • 检定锰。有机合成。
  • 乙酰水杨酸靠抑制环化加氧酶(cyclooxygenase,前列腺素H合成酶)阻止前列腺索的生产,特别是针对COX-1同种型有很高的选择性。其抗血栓效果就是由于抑制了血小板中起凝血和血小板凝聚作用的COX-1。

相关文献及参考

  • Merck: 14,851 Beilstein:10(4)138
  • Merck: 14,851
  • Gilroy, D. W., et al., Differential effects of inhibitors of cyclooxygenase (COX-1 and COX-2) in acute inflammation. Eur. J. Pharmacol. 355 , 211-217, (1998)

安全信息

GHS Symbol
WGK Germany1
Hazard statements
  • H301 Toxic if swallowed 吞食有毒
  • H302 Harmful if swallowed 吞食有害
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Hazard Codes Xn
RTECSVO0700000
Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前,切勿操作。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P263 Avoid contact during pregnancy/while nursing. 怀孕/哺乳期间避免接触。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
  • P284 Wear respiratory protection.? 佩戴呼吸保护装置。
  • P285 In case of inadequate ventilation wear respiratory protection. 在通风不足的情况下,戴呼吸防护。
  • P301+P312
  • P302+P352
  • P304+P340
  • P304+P341
  • P305+P351+P338
  • P307+P311
  • P308+P313
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
  • P314 Get medical advice/attention if you feel unwell. 获取医疗咨询/就医,如果你觉得不舒服
  • P321 Specific treatment (see … on this label). 具体治疗(见本标签上的)。
  • P330 Rinse mouth. 漱口
  • P332+P313
  • P337+P313
  • P342+P311
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word
Safety Statements
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R22 Harmful if swallowed 吞咽有害
UN Number UN 1851 1851 2811
Packing GroupIII
Storage condition 2-8°C {LY} 2-8°C Store at RT. {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C
Hazard Class6.1
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York,
   Academic Press, Inc., 1969  Volum

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - hamster
DOSE/DURATION           : 3500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ATSUDG Archives of Toxicology, Supplement.  (Springer-Verlag New York, Inc.,
   Service Center, 44 Hartz Way, Secaucus, NJ 07094)  No.1-    1978-
   Volume(issue)/page/year: 7,365,1984

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - child
DOSE/DURATION           : 39 mg/kg/13D-I
TOXIC EFFECTS :
   Liver - hepatitis (hepatocellular necrosis), diffuse
REFERENCE :
   AJDCAI American Journal of Diseases of Children.  (AMA, 535 N. Dearborn St.,
   Chicago, IL 60610) V.1-80(3), 1911-50; V.100-    1960-
   Volume(issue)/page/year: 139,453,1985

TYPE OF TEST            : TDLo - Lowest pu

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - species unspecified
DOSE/DURATION           : 1750 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IJMRAQ Indian Journal of Medical Research.  (Indian Council of Medical
   Research, Ansari Nagar, New Delhi 110 029, India)  V.1-    1913-
   Volume(issue)/page/year: 81,621,1985

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous

TYPE OF TEST            : DNA repair
TEST SYSTEM             : Bacteria - Bacillus subtilis
DOSE/DURATION           : 5 mg/disc
REFERENCE :
   JNUDAT Journal of Nihon University School of Dentistry.  (Nihon University
   School of Dentistry, 1-8-13 Surugadai, Kanda, Chiyoda-ku, Tokyo, 101, Japan)
    V.1-    1958-  Volume(issue)/page/year: 34,183,1992

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Human Fibroblast
DOSE/DURATION           : 100 mg/L
REFERENCE :
   ACYTAN Acta Cytologica.  (Science Printers and Pub., Inc., 2 Jacklynn Ct.,
   St. Louis, MO 63132) V.1-    1957-  Volume(issue)/page/year: 16,41,1972

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 100 umol/L
REFERENCE :
   FEPRA7 Federation Proceedings, Federation of American Societies for
   Experimental Biology. (Bethesda, MD)  V.1-46, 1942-87.
   Volume(issue)/page/year: 36,1748,1977

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 1660 mg/L
REFERENCE :
   GMCRDC Gann Monograph on Cancer Research.  (Plenum Pub. Corp., 233 Spring
   St., New York, NY 10013) No. 11-    1971-  Volume(issue)/page/year:
   27,95,1981

TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - rat Embryo
DOSE/DURATION           : 108 ug/plate
REFERENCE :
   JJATDK JAT, Journal of Applied Toxicology.  (John Wiley & Sons Ltd., Baffins
   Lane, Chichester, W. Sussex PO19 1UD, UK)  V.1-    1981-
   Volume(issue)/page/year: 1,190,1981

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 75 mg/L
REFERENCE :
   NEZAAQ Nippon Eiseigaku Zasshi.  Japanese Journal of Hygiene.  (Nippon Eisei
   Gakkai, c/o Kyoto Daigaku Igakubu, Konoe-cho, Yoshida,

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE                    : 17280 mg/kg
SEX/DURATION            : female 1-39 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - cardiovascular
   (circulatory) system
   Reproductive - Specific Developmental Abnormalities - respiratory system
   Reproductive - Effects on Newborn - Apgar score (human only)
REFERENCE :
   JOPDAB Journal of Pediatrics.  (C.V. Mosby Co., 11830 Westline Industrial
   Dr., St. Louis, MO 63141) V.1-    1932-  Volume(issue)/page/year:
   92,478,1978

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE                    : 546 mg/kg
SEX/DURATION            : female 37-39 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - other postnatal measures or effects
REFERENCE :
   CPEDAM Clinical Pediatrics (Philadelphia).  (Lippincott/Harper, Journal
   Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740)  V.1-    1962-
   Volume(issue)/page/year: 32,740,1993

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE                    : 700 mg/kg
SEX/DURATION            : female 35-36 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
   Reproductive - Specific Developmental Abnormalities - cardiovascular
   (circulatory) system
   Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
   CPEDAM Clinical Pediatrics (Philadelphia).  (Lippincott/Harper, Journal
   Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740)  V.1-    1962-
   Volume(issue)/page/year: 34,174,1995

TYPE OF TEST            : T

其他信息

  • 用途五:是应用最早,最广和最普通解热镇痛药抗风湿药。具有解热、镇痛、抗炎、抗风温和抗血小板聚集等多方面的药理作用,发挥药效迅速,药效肯定,超剂量易于诊断和处理,很少发生过敏反应。常用于感冒发热,头痛、神经痛关节痛、肌肉痛、风湿热、急性内湿性关节炎、类风湿性关节炎及牙痛等。是《国家基本药物目录》列入的品种乙酰水杨酸也是其他药物的中间体。
  • 无气味。微带酸味。在干燥空气中稳定,在潮湿空气中逐渐水解成水杨酸和乙酸。遇沸水或溶于氢氧化钠碱溶液和碳酸碱溶液中全部分解。溶于乙醇、乙醚和氯仿。
  • 用途二:用于制造室外及有强光照射的结构件、器械部件,如汽车车身、农机部件、电表和电灯罩、道路标记等
  • 下游产品:华法林 --> 邻乙酰水杨酰氯 --> 2-乙酰氧基苯甲酸-4-乙酰氨基苯
  • 方法一:其制备方法是先将水杨酸与乙酐投入三口瓶中搅拌,反应温度不超过60℃,约1h后,反应结束,倒入冰水中,有结晶析出,过滤、干燥得产品。
  • 毒性分级:高毒
  • Alfa Aesar:O-乙酰基水杨酸,99% O-Acetylsalicylic acid, 99%(50-78-2)
  • 用途三:解热镇痛药,用于发热、疼痛及类风湿关节炎等
  • {Chemical
  • 乙酰水杨酸是什么:乙酰水杨酸又叫阿司匹林、醋柳酸、邻乙酰水杨酸,是由水杨酸与无水醋酸相作用而成的一种解热镇痛药。外观为白色结晶性粉末,纯品无臭,在干燥空气中稳定,遇潮即缓缓水解成水杨酸和醋酸,水溶液呈酸性反应。微溶于水,溶于乙醇、乙醚、氯仿、氢氧化钠溶液和碳酸钠溶液。乙酰水杨酸有解热镇痛、消炎、抗风湿作用,故常用于发热、头痛、肌肉痛、神经痛、风湿热、急性风湿性关节炎、痛风等;乙酰水杨酸也有抗血小板凝集作用,可用于预防动脉血栓、动脉粥样硬化、暂时性脑缺血、心肌梗塞;另外乙酰水杨酸还可用于治疗胆道蛔虫症、足癣等。 【药理作用】乙酰水杨酸是传统的解热镇痛药,同时有抗血小板聚集的作用。乙酰水杨酸在体内具有抗血栓的特性,能减少周围动脉内阻塞性血栓的形成。抑制血小板的释放反应以及内源性ADP、5-HT等的释放。因此,抑制血小板的第二相聚集而不抑制其第一相聚集。乙酰水杨酸的作用机制在于使血小板的环氧酶乙酰化,从而抑制了环内过氧化物的形成,TXA2的
  • 灭火剂:雾状水、泡沫、二氧化碳、砂土。
  • 下游产品:华法林 --> 邻乙酰水杨酰氯 --> 2-乙酰氧基苯甲酸-4-乙酰氨基苯酯
  • 乙酰水杨酸是什么:乙酰水杨酸又叫阿司匹林、醋柳酸、邻乙酰水杨酸,是由水杨酸与无水醋酸相作用而成的一种解热镇痛药。外观为白色结晶性粉末,纯品无臭,在干燥空气中稳定,遇潮即缓缓水解成水杨酸和醋酸,水溶液呈酸性反应。微溶于水,溶于乙醇、乙醚、氯仿、氢氧化钠溶液和碳酸钠溶液。乙酰水杨酸有解热镇痛、消炎、抗风湿作用,故常用于发热、头痛、肌肉痛、神经痛、风湿热、急性风湿性关节炎、痛风等;乙酰水杨酸也有抗血小板凝集作用,可用于预防动脉血栓、动脉粥样硬化、暂时性脑缺血、心肌梗塞;另外乙酰水杨酸还可用于治疗胆道蛔虫症、足癣等。 【药理作用】乙酰水杨酸是传统的解热镇痛药,同时有抗血小板聚集的作用。乙
  • Acros Organics:乙酰水杨酸 Acetylsalicyli
  • 邻乙酰水杨酸价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 LA1248801 乙酰水杨酸;2-乙酸基苯甲酸;阿司匹林;乙酰基柳酸;醋柳酸 100g 188元 2011/08/23 LA1248802 乙酰水杨酸;2-乙酸基苯甲酸;阿司匹林;乙酰基柳酸;醋柳酸 500g 383元 2011/08/23 L
  • Sigma Aldrich:50-78-2(sigmaaldrich)
  • color:white
  • 用途一:杨酸与乙酸。微溶于水,溶于乙醇、乙醚、氯仿,也溶于氢氧化碱溶液或碳酸溶液,同时分解。常用的解热镇痛药。用于解热、镇痛、抗风湿,促进痛风患者尿酸的排泄,抗血小板聚集及胆道蛔虫治疗。
  • 方法二:水杨酸乙酰化而得:在反应罐中加乙酐(加料量为水杨酸总量的0.7889倍),再加入三分之二量的水杨酸,搅拌升温,在81-82℃反应40-60min。

系列性分类