3-(4-((3-Phenoxybenzyl)Amino)Phenyl)Propanoic Acid 4-[[(3-苯氧苯基)甲基]氨基]苯基乙酸
CAS 885101-89-3 MFCD09753282
化学结构图
SMILES: OC(=O)CCC1C=CC(=CC=1)NCC1C=C(C=CC=1)OC1C=CC=CC=1
化学属性
| Mol. Formula | C22H21NO3 |
|---|---|
| Mol. Weight | 347 |
别名和识别编码
| Chemical Name | 3-(4-((3-Phenoxybenzyl)Amino)Phenyl)Propanoic Acid |
|---|---|
| Synonym | 4-(3-Phenoxybenzylamino)phenylpropionic acid GW9508 |
| MDL Number | MFCD09753282 |
| Chemical Name Translation | 4-[[(3-苯氧苯基)甲基]氨基]苯基乙酸 |
| PubChem Substance ID | 329799992 |
| CAS Number | 885101-89-3 |
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分类
- {SNA} Bioactive Small Molecule Alphabetical Index, G, Lipids in Cell Signaling, Other Bioactive Lipids, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
- {SNA} Cell Biology, Cell Signaling and Neuroscience, Lipids in Cell Signaling, Other Bioactive Lipids
相关文献及参考
- [2]. Fujita T, et al. A GPR40 agonist GW9508 suppresses CCL5, CCL17, and CXCL10 induction in keratinocytes and attenuates cutaneous immune inflammation. J Invest Dermatol, 2011, 131(8), 1660-1667.
- [3]. Zhao YF, et al. Activation of ATP-sensitive potassium channels in rat pancreatic beta-cells by linoleic acid through both intracellular metabolites and membrane receptor signalling pathway. J Endocrinol, 2008, 198(3), 533-540.
- [4]. Suski M, et al. Anti-atherosclerotic action of GW9508 - Free fatty acid receptors activator - In apoE-knockout mice. Pharmacol Rep. 2019 Aug;71(4):551-555.
- [1]. Briscoe CP, et al. Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of
- [1]. Briscoe CP, et al. Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of agonist and antagonist small molecules. Br J Pharmacol. 2006 Jul;148(5):619-28.
安全信息
GHS Symbol
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- P273 Avoid release to the environment. 避免释放到环境中。
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P305+P351+P338
- P305+P351+P338+P310
- H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。
- H318 Causes serious eye damage 严重伤害眼睛
- H315 Causes skin irritation 会刺激皮肤
- H302 Harmful if swallowed 吞食有害
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
- S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S39 Wear eye/face protection 戴眼睛/面孔保护装置；
- R37/38 Irritating to respiratory system and skin 对呼吸系统和皮肤有刺激性
- R50/53
- R22 Harmful if swallowed 吞咽有害
- R41 Risk of serious damage to eyes 有严重损伤眼睛的危险
