Armodafinil
CAS 112111-43-0 MFCD09841055
化学结构图
SMILES: NC(=O)C[S@@](=O)C(c1ccccc1)c1ccccc1
化学属性
| Mol. Formula | C15H15NO2S |
|---|---|
| Mol. Weight | 273.3501 |
| Appearance | Solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name | Armodafinil |
|---|---|
| CAS Number | 112111-43-0 |
| Synonym | (-)-Modafinil (R)-(-)-Modafinil (R)-Modafinil; 2-[(R)-(Diphenylmethyl)sulfinyl]-acetamide, CEP 10952, CRL 40982, Nuvigil 2-[(R)-(diphenylmethyl)sulfinyl]acetamide Armodafinil CEP-10953; CEP 10953; CEP10953; CRL 40982; CRL-40982; CRL40982; Armodafinil; brand name: Nuvigil. |
| MDL Number | MFCD09841055 |
| PubChem Substance ID | 329825109 |
| Formula | C15H15NO2S |
| IUPAC Name | 2-[(R)-(diphenylmethyl)sulfinyl]acetamide |
| InChIKey | YFGHCGITMMYXAQ-LJQANCHMSA-N |
| InChI | InChI=1S/C15H15NO2S/c16-14(17)11-19(18)15(12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-10,15H,11H2,(H2,16,17)/t19-/m1/s1 |
| Canonical SMILES | O=C(N)C[S@](C(C1=CC=CC=C1)C2=CC=CC=C2)=O |
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资金保障
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分类
- {SNA} AN-AZ, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Neurobiology, Neuroscience, Pharmacologicals, Stimulants, Teva, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
- {SNA} AN-AZ, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Neurobiology, Neuroscience, Pharmacologicals, Stimulants, Teva
- Chiral Reagents
- Neurochemicals
- Pharmaceuticals
- Intermediates & Fine Chemicals,
产品应用
- Armodafinil is discontinued (DEA controlled substance). Armodafinil, also known as CEP-10953, is the R-enantiomer of the racemic synthetic agent Modafinil with central nervous system (CNS) stimulant and wakefulness-promoting activities. Armodafinil appears to inhibit the reuptake of dopamine by binding to the dopamine-reuptake pump, which leads to an increase in extracellular dopamine levels in some brain regions. This agent does not bind to or inhibit several receptors and enzymes that may be involved in sleep/wake regulation and is not a direct- or indirect-acting dopamine receptor agonist.
相关文献及参考
- Saletu, B., et al.: Int. J. Clin. Pharmacol. Res., 9, 183 (1989),
- Chemelli, R.M., et al.: Cell, 98, 437 (1999),
安全信息
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S39 Wear eye/face protection 戴眼睛/面孔保护装置；
GHS Symbol
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P305+P351+P338
- H318 Causes serious eye damage 严重伤害眼睛
- R41 Risk of serious damage to eyes 有严重损伤眼睛的危险
