Vildagliptin 维达列汀
CAS 274901-16-5 MFCD09952339
化学结构图
SMILES: N[C@@H](CC(=O)N1CC2=NN=C(N2CC1)C(F)(F)F)CC1C=C(F)C(F)=CC=1F.OP(O)(O)=O
化学属性
| Mol. Formula | C17H25N3O2 |
|---|---|
| Mol. Weight | 303 |
| Density | 1.27 |
| Boiling Point | 531.3 |
别名和识别编码
| Chemical Name | Vildagliptin |
|---|---|
| CAS Number | 274901-16-5 |
| Synonym | (2S)- |
| Chemical Name Translation | 维达列汀 |
| MDL Number |
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分类
- Amines
- Chiral Reagents
- Heterocycles
- Pharmaceuticals
- Intermediates & Fine Chemicals
产品应用
- It is a new oral anti-hyperglycemic agent of a new dipeptidyl peptidase-IV (DPP-IV) inhibitor class of drugs. Antidiabetic.
相关文献及参考
- [2]. Wu YJ, et al. Dipeptidyl peptidase-4 inhibitor, vildagliptin, inhibits pancreatic beta cell apoptosis in associationwith its effects suppressing endoplasmic reticulum stress in db/db mice. Metabolism. 2015 Feb;64(2):226-35.
- Ahren, B., et al.: Diabetes Care, 27, 2874 (2004),
- Ahren, B., et al.: J. Clin. Endocrinol. Metab., 89, 2078 (2004),
- Barlocco, D., et al.: Curr. Opin. Invest. Drugs, 5, 1094 (2004),
- [1]. Villhauer EB, et al. 1-[[(3-hydroxy-1-adamantyl)amino]acetyl]-2-cyano-(S)-pyrrolidine: a potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitor with antihyperglycemic properties. J Med Chem. 2003 Jun 19;46(13):2774-89.
- [1]. Villhauer EB, et al. 1-[[(3-hydroxy-1-adamantyl)amino]acetyl]-2-cyano-(S)-pyrrolidine: a potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitor with antihyperglycemic properties. J Med Chem. 2003 Jun 19;46(13):2774-89.
- [2]. Wu YJ, et al. Dipeptidyl peptidase-4 in
安全信息
GHS Symbol
