SU6656 is a potent and selective dual inhibitor of Src family kinases and Aurora kinase. SU6656 modulates CTGF (connective tissue growth factor) expression in an ERK-dependent manner. SU6656 induces caspase-independent cell death in FRO anaplastic thyroid carcinoma cells and therapeutic synergy in human synovial sarcoma growth, invasion and angiogenesis in vivo. 2,3-二氢-N,N-二甲基-2-氧代-3-[(4,5,6,7-四氢-1H-吲哚-2-基)亚甲基]-1H-吲哚-5-磺酰胺
CAS 330161-87-0 MFCD10565928
化学结构图
SMILES: CN(C)S(=O)(=O)c1ccc2c(c1)/C(=C/c1cc3c([nH]1)CCCC3)C(=O)N2
化学属性
| Mol. Formula | C19H21N3O3S |
|---|---|
| Mol. Weight | 371.45 |
| Appearance | Solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name | SU6656 is a potent and selective dual inhibitor of Src family kinases and Aurora kinase. SU6656 modulates CTGF (connective tissue growth factor) expression in an ERK-dependent manner. SU6656 induces caspase-independent cell death in FRO anaplastic thyroid carcinoma cells and therapeutic synergy in human synovial sarcoma growth, invasion and angiogenesis in vivo. |
|---|---|
| Synonym | 2,3-Dihydro-N,N-dimethyl-2-oxo-3-[(4,5,6,7-tetrahydro-1H-indol-2-yl)methylene]-1H-indole-5-sulfonamide SU 6656 SU6656; SU 6656; SU-6656. |
| MDL Number | MFCD10565928 |
| PubChem Substance ID | 24278818 |
| CAS Number | 330161-87-0 |
| Chemical Name Translation | 2,3-二氢-N,N-二甲基-2-氧代-3-[(4,5,6,7-四氢-1H-吲哚-2-基)亚甲基]-1H-吲哚-5-磺酰胺 |
| Formula | C19H21N3O3S |
| IUPAC Name | (Z)-N,N-dimethyl-2-oxo-3-((4,5,6,7-tetrahydro-1H-indol-2-yl)methylene)indoline-5-sulfonamide |
| InChIKey | LOGJQOUIVKBFGH-YBEGLDIGSA-N |
| InChI | InChI=1S/C19H21N3O3S/c1-22(2)26(24,25)14-7-8-18-15(11-14)16(19(23)21-18)10-13-9-12-5-3-4-6-17(12)20-13/h7-11,20H,3-6H2,1-2H3,(H,21,23)/b16-10- |
| Canonical SMILES | O=S(C1=CC2=C(NC(/C2=C\C(N3)=CC4=C3CCCC4)=O)C=C1)(N(C)C)=O |
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分类
- {SNA} Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, Kinase/Phosphatase Biology, Non-Receptor Tyrosine Kinase Biology, Non-Receptor Tyrosine Kinase Inhibitors, Protein Kinase Inhibitors, R to Z, S, Src Kinase, v-Src Sarcoma (Schmidt-Ruppin A-2) Viral Oncogene Homolog (Src)
- {SNA} Bioactive Small Molecule Alphabetical Index, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Kinase/Phosphatase Biology, Non-Receptor Tyrosine Kinase Biology, Non-Receptor Tyrosine Kinase Inhibitors, Protein Kinase Inhibitors, R to Z,
产品应用
- SU6656 is a potent and selective dual inhibitor of Src family kinases and Aurora kinase. SU6656 modulates CTGF (connective tissue growth factor) expression in an ERK-dependent manner. SU6656 induces caspase-independent cell death in FRO anaplastic thyroid carcinoma cells and therapeutic synergy in human synovial sarcoma growth, invasion and angiogenesis in vivo.
相关文献及参考
- Blake, R.A., et al, SU6656, a selective Src family kinase inhibitor, used to probe growth factor signaling. Mol. Cell. Biol. 20 , 9018-9027 , (2000) 摘要
