(2Z)-4-Oxo-4-[3-(Trifluoromethyl)-5,6-Dihydro[1,2,4]Triazolo[4,3-a]Pyrazine-7(8H)-Yl]-1-(2,4,5-Trifluorophenyl)But-2-En-2-Amine (2Z)-4-氧代-4-[3-(三氟甲基)-5,6-二氢-[1,2,4]三唑并[4,3-a]吡嗪-7(8H)-基]-1-(2,4,5-三氟苯基)丁-2-烯-2-胺
CAS 767340-03-4 MFCD12031551
化学结构图
SMILES: N/C(/CC1C=C(F)C(F)=CC=1F)=C\C(=O)N1CC2=NN=C(N2CC1)C(F)(F)F
化学属性
| Mol. Formula | C16H13F6N5O |
|---|---|
| Mol. Weight | 405.3 |
别名和识别编码
| Chemical Name | (2Z)-4-Oxo-4-[3-(Trifluoromethyl)-5,6-Dihydro[1,2,4]Triazolo[4,3-a]Pyrazine-7(8H)-Yl]-1-(2,4,5-Trifluorophenyl)But-2-En-2-Amine |
|---|---|
| CAS Number | 767340-03-4 |
| Synonym | (2Z)-3-Amino-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-2-buten-1-one 2,3-Desdihydrogen rac-Sitagliptin |
| LabNetwork Molecule ID | LN00188078 |
| Chemical Name Translation | (2Z)-4-氧代-4-[3-(三氟甲基)-5,6-二氢-[1,2,4]三唑并[4,3-a]吡嗪-7(8H)-基]-1-(2,4,5-三氟苯基)丁-2-烯-2-胺 |
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分类
- Inhibitors
- Heterocycles
- Intermediates
- Inhibitors
- Pharmaceuticals
- Intermediates & Fine Chemicals,
产品应用
- Sitagliptin intermediate. A dipeptidyl peptidase-4 inhibitor and an anti-hypertensive agent for the treatment of diabetes and hypertension.
相关文献及参考
- Kim, D., et al.: J. Med. Chem., 48, 141 (2005),
- Ahren, B., et al.: Eur. J. Pharmacol., 521 164 (2005),
