(R)-4-(4-((4'-Chloro-[1,1'-Biphenyl]-2-Yl)Methyl)Piperazin-1-Yl)-N-((4-((4-(Dimethylamino)-1-(Phenylthio)Butan-2-Yl)Amino)-3-Nitrophenyl)Sulfonyl)Benzamide (R)-4-(4-((4'-氯-[1,1'-联苯]-2-基)甲基)哌嗪-1-基)-N-((4-((4-(二甲氨基)-1-(苯硫基)丁基-2-基)氨基)-3-硝基苯基)磺酰)苯甲酰胺
CAS 852808-04-9 MFCD12756212
信息真实价格透明
资金保障
专业采购外包团队在线服务
信息真实价格透明
资金保障
专业采购外包团队在线服务
品牌质保精细包装
现货库存
一流品牌服务
分类
- Chiral Reagents
- Inhibitors
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Sulfur & Selenium Compounds
产品应用
- ABT-737 is an orally available inhibitor of the nuclear enzymes poly(ADP-ribose) polymerase (PARP) 1 and 2, with potential antineoplastic activity. Upon administration, ABT-767 selectively binds to PARP 1 and 2, thereby preventing repair of damaged DNA via the base excision repair (BER) pathway. This agent enhances the accumulation of DNA strand breaks and promotes genomic instability eventually leading to apoptosis. ABT-767 may enhance the cytotoxicity of DNA-damaging agents and reverse tumor cell chemo- and radioresistance.
相关文献及参考
- ########
安全信息
GHS Symbol