CPPHA

CAS 693288-97-0 MFCD12912405

化学结构图

693288-97-0
SMILES: OC1=CC=CC=C1C(=O)NC1C=CC(Cl)=CC=1CN1C(=O)C2C=CC=CC=2C1=O

化学属性

Mol. FormulaC22H15ClN2O4
Mol. Weight406.82

别名和识别编码

Chemical NameCPPHA
Synonym N-[4-Chloro-2-(phthalimidomethyl)phenyl]salicylamide N-[4-Chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-hydroxybenzamide CPPHA
MDL NumberMFCD12912405
Chemical Name Translation
信息真实价格透明    资金保障    专业采购外包团队在线服务   
信息真实价格透明    资金保障    专业采购外包团队在线服务   
品牌质保精细包装    现货库存    一流品牌服务   

分类

  • {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, CI-CZ, Excitatory Amino Acids, Excitatory Amino Acids - Metabotropic Antagonists, Fluorination Ready Pharma-Developed Compounds, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, Ion Channels, Ionotropic Glutamate Receptor Modulators, Ligand-Gated Ion Channels, Membrane Protein Biology Tools, Merck & Co., Metabotropic Antagonists, Neuroscience, Neurotransmission, Neurotransmitters, 生化试剂, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学, 蛋白质及衍生物
  • {SNA} Approved Therapeutics/Drug Candidates, Biochemicals and Reagents,

相关文献及参考

  • [2]. N-{4-Chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-hydroxybenzamide (CPPHA) acts through a novel site as a positive allosteric modulator of group 1 metabotropic glutamate receptors. Mol Pharmacol. 2008 Mar;73(3):909-18.
  • [3]. Liu F, et al. The effect of mGlu5 receptor positive allosteric modulators on signaling molecules in brain slices. Eur J Pharmacol. 2006 May 1;536(3):262-8.
  • [4]. Zhang Y, et al. Allosteric potentiators of metabotropic glutamate receptor subtype 5 have differential effects on different signaling pathways in cortical astrocytes. J Pharmacol Exp Ther. 2005 Dec;315(3):1212-9.
  • [1]. O'Brien JA, et al. A novel selective allosteric modulator potentiates the activity of native metabotropic glutamate recept
  • [1]. O'Brien JA, et al. A novel selective allosteric modulator potentiates the activity of native metabotropic glutamate receptor subtype 5 in rat forebrain. J Pharmacol Exp Ther. 2004 May;309(2):568-77.

安全信息

Safety Statements
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置;
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中,参考特别指示/安全收据说明书;
GHS Symbol
WGK Germany3
Precautionary statements
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P273 Avoid release to the environment. 避免释放到环境中。
Hazard statements
  • H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。
Signal word Warning
Hazard Codes N
Risk Statements
  • R50/53

系列性分类


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