(R)-2-Chloro-6-(2-Hydroxy-3-((2-Methyl-1-(Naphthalen-2-Yl)Propan-2-Yl)Amino)Propoxy)Benzonitrile Hydrochloride (R)-2-氯-6-(2-羟基-3-((2-甲基-1-(萘-2-基)丙-2-基)氨基)丙氧基)苯甲腈盐酸盐

CAS 324523-20-8 MFCD16038896

化学结构图

324523-20-8
SMILES:

化学属性

Mol. Weight445.38
Mol. FormulaC24H25ClN2O2· HCl

别名和识别编码

Synonym 2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]-benzonitrile hydrochloride (1:1) NPS-2143 hydrochloride SB-262470-A hydrochloride NPS2143 hydrochloride
Chemical Name(R)-2-Chloro-6-(2-Hydroxy-3-((2-Methyl-1-(Naphthalen-2-Yl)Propan-2-Yl)Amino)Propoxy)Benzonitrile Hydrochloride
MDL NumberMFCD16038896
PubChem Substance ID329825364
Chemical Name Translation(R)-2-氯-6-(2-羟基-3-((2-甲基-1-(萘-2-基)丙-2-基)氨基)丙氧基)苯甲腈盐酸盐
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分类

  • {SNA} Bioactive Small Molecule Alphabetical Index, Calcium Antagonists, Intracellular Calcium Signaling, N, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
  • {SNA} Calcium Antagonists, Cell Biology, Cell Signaling and Neuroscience, Intracellular Calcium Signaling

相关文献及参考

  • [2]. Marquis, Robert W.; Lago, Amparo M.; Callahan, James F.;Antagonists of the Calcium Receptor. 2. Amino Alcohol-Based Parathyroid Hormone Secretagogues. Journal of Medicinal Chemistry (2009), 52(21), 6599-6605.
  • [3]. Yamamura A, Guo Q, Yamamura H, Zimnicka AM, Pohl NM, Smith KA, Fernandez RA, Zeifman A, Makino A, Dong H, Yuan JX.Enhanced Ca2+-sensing receptor function in idiopathic pulmonary arterial hypertension.Circ Res. 2012 Aug 3;111(4):469-81. Epub 2012 Jun 22.
  • [4]. Nakajima S, Hira T, Hara H.Calcium-sensing receptor mediates dietary peptide-induced CCK secretion in enteroendocrine STC-1 cells.Mol Nutr Food Res. 2012 May;56(5):753-60.
  • [5]. Davey AE, Leach K, Valant C, Conigrave AD, Sexton PM, Christopoulos A.Positive and negative allosteric modulators promote biased signaling at the calcium-sensing receptor.Endocrinology. 2012 Mar;153(3):1232-41. Epub 2011 Dec 30.
  • [6]. Nemeth EF, et al. Calcilytic compounds: potent and select

安全信息

Safety Statements
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
GHS Symbol
Precautionary statements
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
Hazard statements
  • H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。
  • H302+H312+H332
WGK Germany3
Signal word Warning
Hazard Codes Xn,N
Risk Statements
  • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
  • R50/53

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Intracellular Calcium Signaling - Cell Signaling and Neuroscience
  5. Calcium Antagonists - Intracellular Calcium Signaling
  1. Medical Research Areas
  2. GPCR & G Protein
  3. CaSR  (钙敏感受体)

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