GW788388 Hydrate

CAS N/A MFCD20527321

化学结构图

N/A
SMILES:

化学属性

Mol. Weight425.48 (anhydrous basis)
Mol. FormulaC25H23N5O2· xH2O

别名和识别编码

Synonym 4-{4-[3-(Pyridin-2-yl)-1H-pyrazol-4-yl]-pyridin-2-yl}-N-(tetrahydro-2H-pyran-4-yl)benzamide hydrate GW788388 Hydrate
MDL NumberMFCD20527321
Chemical NameGW788388 Hydrate
PubChem Substance ID329825168
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分类

  • {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Cytokines and Growth Factors, Cytokines, Growth Factors and Hormones, G, GlaxoSmithKline, Kinase/Phosphatase Biology, Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors, TGF-β Inhibitors, Transforming Growth Factor-β (TGF-β) and Superfamily, Transforming Growth Factor-β Type I Receptor Kinase (ALK5), 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
  • {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Cytokines and Growth Factors, Cytokines, Growth Factors and Hormones, G,

相关文献及参考

  • Lagares D, et al., Endothelin 1 contributes to the effect of transforming growth factor beta1 on wound repair and skin fibrosis. Arthritis Rheum. 62 , 878-889, (2010) 摘要
  • Petersen M, et al., Oral administration of GW788388, an inhibitor of TGF-beta type I and II receptor kinases, decreases renal fibrosis. Kidney Int. 73 , 705-715, (2008) 摘要
  • Tan SM, et al., Targeted inhibition of activin receptor-like kinase 5 signaling attenuates cardiac dysfunction following myocardial infarction. Am. J. Physiol. Heart Circ. Physiol. 298 , H1415-1425, (2010) 摘要

安全信息

GHS Symbol
Precautionary statements
  • P301+P310
  • P273 Avoid release to the environment. 避免释放到环境中。
Hazard statements
  • H400 Verytoxictoaquaticlife 对水生生物毒性非常大。
  • H301 Toxic if swallowed 吞食有毒
WGK Germany3
Signal word Danger
Safety Statements
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
Hazard Codes T,N
Risk Statements
  • R25 Toxic if swallowed 吞咽有毒
  • R50/53

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Cytokines, Growth Factors and Hormones - Cell Signaling and Neuroscience
  5. Cytokines and Growth Factors - Cytokines, Growth Factors and Hormones
  6. Transforming Growth Factor-β (TGF-β) and Superfamily - Cytokines and Growth Factors
  7. TGF-β Inhibitors - Transforming Growth Factor-β (TGF-β) and Superfamily

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