Bcr-Abl

下级目录

DCC-2036

PD-173955

PHA-680626

PYR41

Danusertib

AP23848

3-[2-[2-cyclopentyl-6-(4-diMethylphosphorylanilino)purin-9-yl]ethyl]phenol

Ganetespib

XL228

NVP-HSP990(HSP990)

PACRITINIB

Geldanamycin

Bosutinib

GNF-2

PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE, 6-(2,6-DICHLOROPHENYL)-2-[(4-FLUORO-3-METHYLPHENYL)AMINO]-8-METHYL-

NVP-BHG712

目录项下的产品

1020172-07-9 / MFCD120172079
4-(4-(3-(3-(Tert-Butyl)-1-(Quinolin-6-Yl)-1H-Pyrazol-5-Yl)Ureido)-3-Fluorophenoxy)-N-Methylpicolinamide
4-(4-(3-(3-(叔丁基)-1-(喹啉-6-基)-1H-吡唑-5-基)脲基)-3-氟苯氧基)-N-甲基吡啶酰胺

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

260415-63-2 / MFCD60415632
PD-173955 is a src tyrosine kinase inhibitor. PD173955 inhibited Bcr-Abl-dependent cell growth. PD173955 showed cell cycle arrest in G(1). PD173955 has an IC(50) of 1-2 nM in kinase inhibition assays of Bcr-Abl, and in cellular growth assays it inhibits Bcr-Abl-dependent substrate tyrosine phosphorylation. PD173955 inhibited kit ligand-dependent c-kit autophosphorylation (IC(50) = approximately 25 nM) and kit ligand-dependent proliferation of M07e cells (IC(50) = 40 nM) but had a lesser effect on interleukin 3-dependent (IC(50) = 250 nM) or granulocyte macrophage colony-stimulating factor (IC(50) = 1 microM)-dependent cell growth.

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

398493-74-8 / MFCD98493748
PHA-680626 is a potent and selective PLK inhibitor. PHA-680626 exhibits anti-proliferative and pro-apoptotic activity on Imatinib-resistant chronic myeloid leukemia cell lines and primary CD34+ cells by inhibition of both Bcr-Abl tyrosine kinase and Aurora kinases. PHA-680626 inhibits Plk1 (IC50 = 0.53 μM), Plk2 (IC50 = 0.07 μM) and Plk3 (IC50 = 1.61 μM).

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

418805-02-4 / MFCD18805024
Ethyl-4-[4-[(5-Nitro-2-Furanyl)Methylene]-3,5-Dioxo-1-Pyrazolyl]Benzoate
4-[4-[(5-硝基-2-呋喃基)亚甲基]-3,5-二氧代-1-吡唑烷基]苯甲酸乙酯

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

827318-97-8 / MFCD27318978
(R)-N-(5-(2-Methoxy-2-Phenylacetyl)-1,4,5,6-Tetrahydropyrrolo[3,4-c]Pyrazol-3-Yl)-4-(4-Methylpiperazin-1-Yl)Benzamide
(R)-N-(5-(2-甲氧基-2-苯乙酰基)-1,4,5,6-四氢吡咯并[3,4-c]吡唑-3-基)-4-(4-甲基哌嗪-1-基)苯甲酰胺

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

中华人民共和国

834894-21-2 / MFCD34894212
AP23848 is a potent Bcr-Abl inhibitor. In a murine model, AP23848 inhibited activation-loop mutant Kit phosphorylation and tumor growth.

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

845895-51-4 / MFCD45895514
3-[2-[2-cyclopentyl-6-(4-diMethylphosphorylanilino)purin-9-yl]ethyl]phenol
AP23464

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

888216-25-9 / MFCD88216259
Ganetespib
Ganetespib

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

中华人民共和国

898280-07-4 / MFCD98280074
XL228

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

934343-74-5 / MFCD034343745
(R)-2-Amino-7-(4-Fluoro-2-(6-Methoxypyridin-2-Yl)Phenyl)-4-Methyl-7,8-Dihydropyrido[4,3-d]Pyrimidin-5(6H)-One
(R)-2-氨基-7-(4-氟-2-(6-甲氧基吡啶-2-基)苯基)-4-甲基-7,8-二氢吡啶并[4,3-d]嘧啶-5(6H)-酮

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

937272-79-2 / MFCD037272792
PACRITINIB
Pacritinib游离态

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

30562-34-6 / MFCD00274570
Geldanamycin
格尔德霉素

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

中华人民共和国
北京市
√

380843-75-4 / MFCD07367846
4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile
4-[(2,4-二氯-5-甲氧基苯基)氨基]-6-甲氧基-7-[3-(4-甲基-1-哌嗪)丙氧基]-3-喹啉甲腈

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

中华人民共和国
√

778270-11-4 / MFCD09265253
3-[6-[[4-(Trifluoromethoxy) Phenyl] Amino]-4-Pyrimidinyl] Benzamide
3-[6-[[4-(三氟甲氧基)苯基]氨基]-4-嘧啶基]苯甲酰胺

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

287204-45-9 / MFCD10565929
PD180970 is a novel Bcr-Abl inhbiitor. PD180970 inhibited in vivo tyrosine phosphorylation of p210Bcr-Abl (IC50 = 170 nM) and the p210BcrAbl substrates Gab2 and CrkL (IC50 = 80 nM) in human K562 chronic myelogenous leukemic cells. In vitro, PD180970 potently inhibited autophosphorylation of p210Bcr-Abl (IC50 = 5 nM) and the kinase activity of purified recombinant Abl tyrosine kinase (IC50 = 2.2 nM). Incubation of K562 cells with PD180970 resulted in cell death. PD180970 is among the most potent inhibitors of the p210Bcr-Abl tyrosine kinase, which is present in almost all cases of human chronic myelogenous leukemia. PD180970 is a promising candidate as a novel therapeutic agent for Bcr-Abl-positive leukemia.

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

940310-85-0 / MFCD20272929
4-Methyl-3-((1-Methyl-6-(Pyridin-3-Yl)-1H-Pyrazolo[3,4-D]Pyrimidin-4-Yl)Amino)-N-(3-(Trifluoromethyl)Phenyl)Benzamide
4-甲基-3-((1-甲基-6-(吡啶-3-基)-1H-吡唑并[3,4-d]嘧啶-4-基)氨基)-N-(3-(三氟甲基)苯基)苯甲酰胺

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂