MEK

下级目录

Debio-0932 (CUDC305)

CCT196969

CCT241161

GDC-0623

G-479

(LGX818) Encorafenib

LY3009120

PD318088

Kobe0065

Kobe-2602

CInQ-03

E6201

Binimetinib

AZD-8330

TYRPHOSTIN AG 490

PD 98059

G-573

PD-184352

GW5074

PD 0325901

PD-166866

PD-184161

目录项下的产品

1061318-81-7 / MFCD161318817
Debio-0932 (CUDC305)

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

1163719-56-9 / MFCD263719569
CCT196969

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
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1163719-91-2 / MFCD263719912
CCT241161 is a novel orally available, pan-RAF inhibitor with anti-SRC activity. CCT241161 blocked growth of BRAF-mutant and NRAS-mutant melanoma cells, inhibiting MEKÂ–ERK, in vitro and in vivo. CCT241161 also prevented growth of xenografts derived from patient tumours with acquired or intrinsic resistance to BRAF and MEK inhibitors. BRAF and MEK inhibitors are effective in BRAF mutant melanoma, but most patients eventually relapse with acquired resistance, and others present intrinsic resistance to these drugs.

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
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1168091-68-6 / MFCD268091686
5-((2-Fluoro-4-Iodophenyl)Amino)-N-(2-Hydroxyethoxy)Imidazo[1,5-A]Pyridine-6-Carboxamide
5-((2-氟-4-碘苯基)氨基)-N-(2-羟基乙氧基)咪唑并[1,5-a]吡啶-6-甲酰胺

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
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1168092-22-5 / MFCD268092225
G-479 is an potent MEK inhibitor. Structurally, G-479 is an analogue of GDC-0623 (or so-call Me-Too drug). G-479 with polarity distributed throughout the molecule was shown improved bioactivity over GDC-0623 in many aspects.

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
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1269440-17-6 / MFCD369440176
(S)-Methyl [1-[[4-[3-[5-chloro-2-fluoro-3-(methylsulfonamido)phenyl]-1-isopropyl-1H-pyrazol-4-yl]pyrimidin-2-yl]amino]propan-2-yl]carbamate
(S)-[1-[[4-[3-[5-氯-2-氟-3-(甲基磺酰胺基)苯基]-1-异丙基-1H-吡唑-4-基]嘧啶-2-基]氨基]丙-2-基]氨基甲酸甲酯

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
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中华人民共和国

1454682-72-4 / MFCD554682724
1-(3,3-Dimethylbutyl)-3-(2-Fluoro-4-Methyl-5-(7-Methyl-2-(Methylamino)Pyrido[2,3-D]Pyrimidin-6-Yl)Phenyl)Urea
1-(3,3-二甲基丁基)-3-(2-氟-4-甲基-5-(7-甲基-2-(甲胺基)吡啶并[2,3-d]嘧啶-6-基)苯基)脲

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
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391210-00-7 / MFCD91210007
PD318088 is a non-ATP competitive allosteric MEK1/2 inhibitor, binds simultaneously with ATP in a region of the MEK1 active site that is adjacent to the ATP-binding site.

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
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436133-68-5 / MFCD36133685
N-(3-Chloro-4-Methylphenyl)-2-[2,6-Dinitro-4-(Trifluoromethyl)Phenyl] Hydrazinothioformamide
N-(3-氯-4-甲基苯基)-2-[2,6-二硝基-4-(三氟甲基)苯基]肼基硫代甲酰胺

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
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454453-49-7 / MFCD54453497
2-(2,6-Dinitro-4-(Trifluoromethyl)Phenyl)-N-(4-Fluorophenyl)Hydrazine-1-Carbothioamide
2-[2,6-二硝基-4-(三氟甲基)苯基]-N-(4-氟苯基)肼基硫代甲酰胺

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
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500272-80-0 / MFCD00272800
CInQ-03 is a novel and specific MEK inhibitor both in vitro and in vivo.

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
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603987-35-5 / MFCD03987355
E6201 is a synthetic, fungal metabolite analogue inhibitor of mitogen-activated protein kinase kinase 1 (MEK-1) and mitogen-activated protein kinase kinase kinase 1 (MEKK-1) with potential antipsoriatic and antineoplastic activities. MEK-1/MEKK-1 inhibitor E6201 specifically binds to and inhibits the activities of MEK-1 and MEKK-1, which may result in the inhibition of tumor cell proliferation. MEK-1 and MEKK-1 are key components in the RAS/RAF/MEK/MAPK signaling pathway, which regulates cell proliferation and is frequently activated in human cancers.

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
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606143-89-9 / MFCD06143899
5-((4-Bromo-2-Fluorophenyl)Amino)-4-Fluoro-N-(2-Hydroxyethoxy)-1-Methyl-1H-Benzo[D]Imidazole-6-Carboxamide
5-((4-溴-2-氟苯基)氨基)-4-氟-N-(2-羟基乙氧基)-1-甲基-1H-苯并[d]咪唑-6-甲酰胺

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

中华人民共和国

869357-68-6 / MFCD69357686
AZD8330, also known as ARRY704 and ARRY424704, is an orally active, selective MEK inhibitor with potential antineoplastic activity. MEK inhibitor AZD8330 specifically inhibits mitogen-activated protein kinase kinase 1 (MEK or MAP/ERK kinase1), resulting in inhibition of growth factor-mediated cell signaling and tumor cell proliferation. MEK is a key component of the RAS/RAF/MEK/ERK signaling pathway that regulates cell growth; constitutive activation of this pathway has been implicated in many cancers.

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
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133550-30-8 / MFCD00209833
(E)-N-Benzyl-2-Cyano-3-(3,4-Dihydroxyphenyl)Acrylamide
(E)-N-苄基-2-氰基-3-(3,4-二羟苯基)丙烯酰胺

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
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167869-21-8 / MFCD00671789
2-(2-Amino-3-Methoxyphenyl)-4H-Chromen-4-One
2-(2-氨基-3-甲氧基苯基)-4H-1-苯并吡喃-4-酮

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
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北京市
√

22868-35-5 / MFCD01438282
G-573 is an allosteric inhibitor of MEK that is both potent and selective. The IC(50) value for pERK inhibition in HCT116 tumours by G-573 was estimated to be 0.406 ÂµM. The IC(50) values for tumour growth inhibition in HCT116 and H2122 were estimated to be 3.43 and 2.56 ÂµM, respectively. ED(50) estimates in HCT116 and H2122 mouse xenograft models were estimated to be ~4.6 and 1.9 mg/kg/day, respectively.

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
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212631-79-3 / MFCD02683961
2-((2-Chloro-4-Iodophenyl)Amino)-N-(Cyclopropylmethoxy)-3,4-Difluorobenzamide
2-[(2-氯-4-碘苯基)氨基]-N-(环丙基甲氧基)-3,4-二氟-苯甲酰胺

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

中华人民共和国
√

220904-83-6 / MFCD03453076
Gw5074
3-(3,5-二溴-4-羟基苯亚甲基)-5-碘-1,3-二氢吲哚-2-酮

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

中华人民共和国
√

391210-10-9 / MFCD08435926
PD0325901
MEK1/2抑制剂III

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

192705-79-6 / MFCD12922514
1-(2-Amino-6-(3,5-Dimethoxyphenyl)Pyrido[2,3-D]Pyrimidin-7-Yl)-3-(Tert-Butyl)Urea
1-(2-氨基-6-(3,5-二甲氧基苯基)吡啶并[2,3-d]嘧啶-7-基)-3-(叔丁基)脲

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

212631-67-9 / MFCD16038897
5-Bromo-2-((2-Chloro-4-Iodophenyl)Amino)-N-(Cyclopropylmethoxy)-3,4-Difluorobenzamide
5-溴-2-((2-氯-4-碘苯基)氨基)-N-(环丙基甲氧基)-3,4-二氟苯甲酰胺

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

中华人民共和国