c-Kit

下级目录

Henatinib

Chiauranib

瓦他拉尼碱二盐酸盐

3-[2,4-dimethyl-5-[(E)-(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propanoic acid

PD-173955

AAL-993

Crenolanib

OSI-930

N-(1,3-Benzodioxol-5-ylmethyl)-4-benzofuro[3,2-d]pyrimidin-4-yl-1-piperazinecarbothioamide

AZD-2932

Ganetespib

TYRPHOSTIN AG 490

SU54161

Masitinib

Tandutinib

1-(2,4-Difluorophenyl)-3-(4-(6,7-dimethoxyquinolin-4-yloxy)-2-fluorophenyl)urea

5-[4-[(2,3-Dimethyl-2H-indazol-6-yl)-methyl-amino]-pyrimidin-2-ylamino]-2-methyl-benzenesulfonamide

目录项下的产品

1239269-51-2 / MFCD339269512
Henatinib maleate is t he maleate salt form of henatinib, an orally bioavalable, multitargeted tyrosine kinase inhibitor with potential antitumor and antiangiogenic activities. Henatinib inhibits vascular endothelial growth factor receptor type 2 (VEGFR2), a tyrosine kinase receptor upregulated in many tumor cells that plays a key role in angiogenesis. This may result in an inhibition of angiogenesis and eventually tumor cell proliferation. Henatinib, structurally similar to sunitinib, also inhibits, though to a lesser extent, mast/stem cell growth factor receptor (c-Kit) and, platelet-derived growth factor receptor (PDGFR) alpha and beta. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

1256349-48-0 / MFCD356349480
N-(2-Aminophenyl)-6-[(7-methoxy-4-quinolinyl)oxy]-1-naphthalenecarboxamide
N-(2-氨基苯基)-6-[(7-甲氧基-4-喹啉基)氧基]-1-萘甲酰胺

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

中华人民共和国

212141-51-0 / MFCD12141510
N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine dihydrochloride
瓦他拉尼二盐酸盐

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

252916-29-3 / MFCD52916293
3-[2,4-dimethyl-5-[(E)-(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propanoic acid

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

260415-63-2 / MFCD60415632
PD-173955 is a src tyrosine kinase inhibitor. PD173955 inhibited Bcr-Abl-dependent cell growth. PD173955 showed cell cycle arrest in G(1). PD173955 has an IC(50) of 1-2 nM in kinase inhibition assays of Bcr-Abl, and in cellular growth assays it inhibits Bcr-Abl-dependent substrate tyrosine phosphorylation. PD173955 inhibited kit ligand-dependent c-kit autophosphorylation (IC(50) = approximately 25 nM) and kit ligand-dependent proliferation of M07e cells (IC(50) = 40 nM) but had a lesser effect on interleukin 3-dependent (IC(50) = 250 nM) or granulocyte macrophage colony-stimulating factor (IC(50) = 1 microM)-dependent cell growth.

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269390-77-4 / MFCD69390774
AAL-993 is a highly potent inhibitor of VEGFR-1 (IC50 =130nM), VEGFR-2 (IC50=23nM) and VEGFR-3 (IC50=18nM). At higher concentrations it inhibits PDGFR-β (640nM), c-Kit (236nM) and CSF-1R (380nM).

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670220-88-9 / MFCD70220889
1-[2-[5-[(3-Methyl-3-Oxetanyl)Methoxy]-1-Benzimidazolyl]-8-Quinolyl]-4-Piperidinamine
[1-[2-[5-(3-甲基氧杂环丁烷-3-基甲氧基)苯并咪唑-1-基]喹啉-8-基]哌啶-4-基]胺

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

728033-96-3 / MFCD28033963
3-((Quinolin-4-Ylmethyl)Amino)-N-(4-(Trifluoromethoxy)Phenyl)Thiophene-2-Carboxamide
3-((喹啉-4-基甲基)氨基)-N-(4-(三氟甲氧基)苯基)噻吩-2-甲酰胺

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

850879-09-3 / MFCD50879093
N-(Benzo[D][1,3]Dioxol-5-Ylmethyl)-4-(Benzofuro[3,2-d]Pyrimidin-4-Yl)Piperazine-1-Carbothioamide
N-(苯并[d][1,3]二氧杂环戊烷-5-基甲基)-4-(苯并呋喃并[3,2-d]嘧啶-4-基)哌嗪-1-甲硫酰胺

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

883986-34-3 / MFCD83986343
AZD-2932 is a high affinity inhibitor of VEFGR-2 and PDGFR. AZD-2932 has a balanced ~ 1:1 ratio of activity vs both VEGFR-2 and PDGFRβ and shows IC50 values of 8 and 4 nM against the two enzymes, respectively. It is also active on c-Kit and FLT3 with good selectivity on a panel of kinases. The pharmacokinetic behavior and the preclinical antitumor activity in nude mice bearing C6 rat glial tumors indicate that 31 has the potential to become an antiangiogenic agent in the clinic.

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
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888216-25-9 / MFCD88216259
Ganetespib
Ganetespib

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

中华人民共和国

133550-30-8 / MFCD00209833
(E)-N-Benzyl-2-Cyano-3-(3,4-Dihydroxyphenyl)Acrylamide
(E)-N-苄基-2-氰基-3-(3,4-二羟苯基)丙烯酰胺

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

204005-46-9 / MFCD01940922
3-((3,5-Dimethyl-1H-Pyrrol-2-yl)Methylene)Indolin-2-One
1,3-二氢-3-[(3,5-二甲基-1H-吡咯-2-基)亚甲基]-2H-吲哚-2-酮

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
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790299-79-5 / MFCD09954132
Masitinib, also known as AB1010, is an orally bioavailable and multi-targeted protein tyrosine kinase inhibitor with potential antineoplastic activity. Masitinib selectively binds to and inhibits both the wild-type and mutated forms of the stem cell factor receptor (c-Kit; SCFR); platelet-derived growth factor receptor (PDGFR); fibroblast growth factor receptor 3 (FGFR3); and, to a lesser extent, focal adhesion kinase (FAK). As a consequence, tumor cell proliferation may be inhibited in cancer cell types that overexpress these receptor tyrosine kinases (RTKs). Masitinib was approved for veterinary use.
马塞替尼

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

中华人民共和国

387867-13-2 / MFCD09954147
N-(4-Isopropoxyphenyl)-4-(6-Methoxy-7-(3-(Piperidin-1-Yl)Propoxy)Quinazolin-4-Yl)Piperazine-1-Carboxamide
N-(4-异丙氧基苯基)-4-(6-甲氧基-7-(3-(哌啶-1-基)丙氧基)喹唑啉-4-基)哌嗪-1-甲酰胺

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

228559-41-9 / MFCD09971092
1-(2,4-difluorophenyl)-3-(4-((6,7-dimethoxyquinolin-4-yl)oxy)-2-fluorophenyl)urea
1-(2,4-二氟苯基)-3-(4-((6,7-二甲氧基喹啉-4-基)氧基)-2-氟苯基)脲

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

444731-52-6 / MFCD11616589
Pazopanib
帕唑帕尼

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

中华人民共和国
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