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TGF-beta

下级目录

GW6604

GW788388

PP1

SB 431542

A-83-01

目录项下的产品

452342-37-9

452342-37-9 / MFCD52342379
GW6604 is a potent and selective ALK-5 inhibitor with potent anticancer activity. GW6604 is also a TGF-beta signaling pathway inhibitor. In vitro, GW6604 inhibited autophosphorylation of ALK5 with an IC(50) of 140 nM and in a cellular assay inhibited TGF-beta-induced transcription of PAI-1 (IC(50): 500 nM). In vivo, GW6604 (40 mg kg(-1) p.o.) increased liver regeneration in TGF-beta-overexpressing mice, which had undergone partial hepatectomy. In an acute model of liver disease, GW6604 reduced by 80% the expression of collagen IA1. Inhibition of ALK5 could be an attractive new approach to treatment of liver fibrotic diseases by both preventing matrix deposition and promoting hepatocyte regeneration. ( Br J Pharmacol. 2005 May;145(2):166-77. ).

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
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452342-67-5

452342-67-5 / MFCD52342675
4-(4-(3-(Pyridin-2-Yl)-1H-Pyrazol-4-Yl)Pyridin-2-Yl)-N-(Tetrahydro-2H-Pyran-4-Yl)Benzamide
4-[4-[3-(吡啶-2-基)-1H-吡唑-4-基]吡啶-2-基]-N-(四氢吡喃-4-基)苯甲酰胺

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

中华人民共和国

172889-26-8

172889-26-8 / MFCD01076570
1-(Tert-Butyl)-3-(p-Tolyl)-1H-Pyrazolo[3,4-d]Pyrimidin-4-Amine
1-(叔丁基)-3-(对甲苯基)-1H-吡唑并[3,4-d]嘧啶-4-胺

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
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√

301836-41-9

301836-41-9 / MFCD05865244
4-[4-(1,3-Benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]benzamide
4-[4-(1,3-苯并二唑-5-基)-5-(2-吡啶基)-1H-咪唑-2-基]-苯酰胺

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

中华人民共和国
√

909910-43-6

909910-43-6 / MFCD08705403
3-(6-Methylpyridin-2-Yl)-N-Phenyl-4-(Quinolin-4-Yl)-1H-Pyrazole-1-Carbothioamide
3-(6-甲基吡啶-2-基)-N-苯基-4-(喹啉-4-基)-1H-吡唑-1-硫代甲酰胺

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
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