GGTI-2133
CAS N/A MFCD07776925
化学结构图
SMILES: CC(C)C[C@H](NC(=O)C1=CC=C(C=C1C1C=CC=C2C=CC=CC2=1)NCC1=CNC=N1)C(O)=O.OC(=O)C(F)(F)F
化学属性
| Mol. Formula | C27H28N4O3· C2HF3O2 |
|---|---|
| Mol. Weight | 570.56 |
| Melting Point | 103-118.5 °C |
别名和识别编码
| Chemical Name | GGTI-2133 |
|---|---|
| Synonym | GGTI-2133 N-[[4-(Imidazol-4-yl)methylamino]-2-(1-naphthyl)benzoyl]leucine trifluoroacetate salt |
| PubChem Substance ID | 24724491 |
| MDL Number | MFCD07776925 |
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分类
- {SNA} Bioactive Small Molecules, Biochemicals and Reagents, Cancer Metabolism, Cancer Research, Cell Biology, D to K, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, G, Geranylgeranyl transferase I, M
- {SNA} Bioactive Small Molecule Alphabetical Index, D to K, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, G, Geranylgeranyl transferase I, 生化试剂, 生物活性小分子, 甲羟戊酸途径中的抑制剂和激活剂, 癌症中的甲羟戊酸途径, 癌症代谢, 癌症研究, 细胞生物学,
相关文献及参考
- , Potent, highly selective, and non-thiol inhibitors of protein geranylgeranyltransferase-I. J. Med. Chem. 42 , 1333-1340, (1999) 摘要
- , Selective inhibition of type-I geranylgeranyltransferase in vitro and in whole cells by CAAL peptidomimetics. Bioorg. Med. Chem. 6 , 293-299, (1998) 摘要
安全信息
GHS Symbol
- H315 Causes skin irritation 会刺激皮肤
- H319 Causes serious eye irritation 严重刺激眼睛
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P305+P351+P338
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S36 Wear suitable protective clothing 穿戴适当的防护服；
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
