CAS 83-49-8 MFCD00003681-Hyodeoxycholic acid 猪去氧胆酸 TAO{mole}

Hyodeoxycholic acid 猪去氧胆酸

CAS 83-49-8 MFCD00003681

化学结构图

SMILES: CC(CCC(=O)O)C1CCC2C3CC(O)C4CC(O)CCC4(C)C3CCC12C

化学属性

Mol. Formula	C24H40O4
Mol. Weight	392.57
Melting Point	200-201°C
TSCA	No
Density	1.128
Appearance	本品能抑制胆酸的形成及溶解脂肪，降低血中胆固醇和甘油三酯。本品是由猪胆汁中提取的一种胆烷酸，为白色或略带微黄色粉末，臭且微腥、味苦。Mp 197℃(分解)。略溶于醇，在丙酮中微溶，在乙醚、氯仿中极微溶，几乎不溶于水。

别名和识别编码

Chemical Name	Hyodeoxycholic acid
CAS Number	83-49-8
Synonym	Hyodeoxycholic acid {LY} Hyodeoxycholic acid a-Hyodeoxycholic Acid alpha-Hyodeoxycholic Acid {} {LY} Hyodeoxycholic acid {} {} {LY} Hyodeoxycholic acid {} {} {} {LY} Hyodeoxycholic acid {} {} {} {} {LY} Hyodeoxycholic acid {} {} {} {} {} {LY} Hyodeoxycholic acid {} {} {} {} {} {} {LY} Hyodeoxycholic acid {} {} {} {} {} {} {} {LY} Hyodeoxycholic acid {} {} {} {} {} {} {} {} {LY} Hyodeoxycholic acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Hyodeoxycholic acid {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {LY} Hyodeoxycholic acid {} {} {} {} {} {} {} {} {} {} {} {LY} Hyodeoxycholic acid {} {} {} {} {} {} {} {} {} {} {} {} {LY} Hyodeoxycholic acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Hyodeoxycholic acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Hyodeoxycholic acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Hyodeoxycholic acid {} {} {} {} {} {} {} {} {} {} {} {}
MDL Number	MFCD00003681
PubChem Substance ID	5283820
EC Number	201-483-2
Merck Number	14,4857
Chemical Name Translation	猪去氧胆酸
Beilstein Registry Number	3218394
LabNetwork Molecule ID	LN01285032
InChI	InChI=1S/C24H40O4/c1-14(4-7-22(27)28)17-5-6-18-16-13-21(26)20-12-15(25)8-10-24(20,3)19(16)9-11-23(17,18)2/h14-21,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15-,16+,17-,18+,19+,20+,21+,23-,24-/m1/s1
Canonical SMILES	C[C@H](CCC(O)=O)[C@H]1CC[C@@]2([H])[C@]3([H])C[C@H](O)[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C

信息真实价格透明资金保障专业采购外包团队在线服务

品牌质保精细包装现货库存一流品牌服务

产品应用

降血脂、降低血中胆固醇、降低转氨酶等。

安全信息

WGK Germany3

Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter

RTECSFZ2050000

Safety Statements

S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
S37 Wear suitable gloves 戴适当手套；

Risk Statements

R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性

Storage condition 2-8°C, protect from light {LY} 2-8°C, protect from light 4℃ {} {LY} 2-8°C, protect from light {} {} {LY} 2-8°C, protect from light {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect f

Signal word Warning

GHS Symbol

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 5600 umol/L
REFERENCE :
   ARTODN Archives of Toxicology.  (Springer-Verlag, Heidelberger Pl. 3, D-1000
   Berlin 33, Fed. Rep. Ger.)  V.32-    1974-  Volume(issue)/page/year:
   60,192,1987

Precautionary statements

P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P302+P352
P304+P340
P305+P351+P338
P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
P332+P313
P337+P313
P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
P403+P233
P405 Store locked up. 上锁保管。
P501 Dispose of contents/container to..… 处理内容物/容器.....

Hazard statements

H315 Causes skin irritation 会刺激皮肤
H319 Causes serious eye irritation 严重刺激眼睛
H335 May cause respiratory irritation 可能导致呼吸道刺激

其他信息

用途三:用于降低血中胆固醇。
图谱信息:猪去氧胆酸(83-49-8)核磁图( 13 CNMR) 猪去氧胆酸(83-49-8)红外图谱(IR1) 猪去氧胆酸(83-49-8)质谱(MS) 猪去氧胆酸(83-49-8)红外图谱(IR2)
Sigma Aldrich:83-49-8(sigmaaldrich)
Alfa Aesar:二羟基胆烷酸,98% Hyodeoxycholic acid, 98%(83-49-8)
用途二:适用于Ia和Ib型高血脂症、动脉粥样硬化症。对百日咳杆菌、白喉杆菌、金黄色葡萄球菌等有一定的抑菌作用。也适用于胆道炎，胆囊炎、胆石症和其他非阻塞性胆汁郁积，可加速胆囊造影剂排出肝脏以有助于显影。能促进肠道脂肪分解和脂溶性维生素的吸收，可用于肝胆疾患引起的消化不良。可用作消炎药，治疗慢性支气管炎、小儿病毒性呼吸道炎症。偶可引起肠胃不适，轻度腹泻等。
用途四:降血脂、降低血中胆固醇、降低转氨酶等。
猪去氧胆酸价格(试剂级):更新日期产品编号产品名称包装价格 2010/05/25 B20506 二羟基胆烷酸, 98% Hyodeoxycholic acid, 98% 5g 497元 2010/05/25 B20506 二羟基胆烷酸, 98% Hyodeoxycholic acid, 98% 25g 1596元 2010/05/25 B20506 二羟基胆烷酸, 98% Hyodeoxycholic acid, 98% 100g 5656元
MOL 文件:83-49-8.mol
TCI Shanghai:猪去氧胆酸 Hyodeoxycholic Acid,>;98.0%(T)(83-49-8)
MSDS 信息:Hyodeoxycholic acid(83-49-8).msds
方法一:以新鲜猪胆汁为原料猪胆汁酸的制备取新鲜猪胆汁，加饱和石灰水上清液加热至沸制备胆红素钙盐，母液趁热加盐酸酸化至刚果红变蓝，析出结合猪胆汁酸的黑色胶状沉淀，除去乳状液，收集沉淀物，加自来水冲洗后变硬变脆，得猪胆汁酸。猪胆汁[饱和石灰水]→[pH11-12, 100℃]母液[HCl]→沉淀物[水]→猪胆汁酸粗品的制备取粗制猪胆汁酸，加1.5倍质量的氢氧化钠，加9倍量体积的水，加热16h以上，冷却，静置分层，倾出上层淡黄色液体，沉淀物加少量水溶解，加稀盐酸或硫酸(2：1)酸化至刚果红试纸变蓝，取出析出物，过滤，水洗至中性，呈金黄色，真空干燥，得粗品。猪胆汁酸[NaOH, 水]→[>;16h]皂化液[HCl]→粗品异去氧胆酸成品的制备取粗品，加5倍量乙酸乙酯，加150-200g/L活性炭，加热搅拌回流溶解，放冷，过滤，滤渣加3倍量乙酸乙酯回流，过滤，合并两次滤液，加200g/L无水硫酸钠，过滤，得滤液。浓缩至原体积的1/5-1/3，放冷，析出晶体，抽滤，得结晶，用乙酸乙酯洗涤，真空干燥，得异去氧胆酸成品。粗品[乙酸乙酯，活性炭]→滤液[无水Na2SO4]→滤液→结晶[乙酸乙酯]→异去氧胆酸成品。
用途一:能降低血中胆固醇，治疗和预防冠心病、高血压等
上游原料:乙酸乙酯 --> 硫酸钠 --> 刚果红试纸 --> 碱性橙 2 --> 胆红素 --> 直接红 28 --> 胆酸钠