Azidotrimethylsilane 叠氮基三甲基硅烷
CAS 4648-54-8 MFCD00001986
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分类
- {SNA} Azidation/Diazo Transfer, Azide Sources, C-X Bond Formation (Non-Halogen), Chemical Biology, Chemical Synthesis, Conjugation Chemistry: Azides, Alkynes and Other Reagents, Materials Science, Micro/NanoElectronics, Self Assembly & Contact Printing, Self-Assembly Materials, Silanes,
- {SNA} Azidation/Diazo Transfer,
- {uni_hamburg} no charge; 1fragment
- Azidation/Diazo Transfer, Azide Sources, C-X Bond Formation (Non-Halogen), Chemical Biology, Chemical Synthesis, Conjugation Chemistry: Azides, Alkynes and Other Reagents, Materials Science, Micro/NanoElectronics, Self Assembly & Contact Printing, Self-Assembly Materials, Silanes, Synthetic Reagents
- {SNA}
产品应用
- A versatile azidonation reagent
相关文献及参考
- In combination with triflic acid, is useful for the direct amination of aromatics. Aminodiazonium triflate is suggested as the active intermediate. Thus, benzene gives aniline in 95% yield and toluene gives a mixture of o- and p-toluidine: J. Org. Chem., 54, 1203 (1989). See also: Tetrahedron Lett., 32, 4321 (1991).
- Curtius reaction with acid halides gives isocyanates in one operation: Synth. Commun., 2, 227 (1972): Synthesis, 551 (1972); J. Org. Chem., 38, 2982 (1973). Similarly, pyridine-2,3-dicarboxylic anhydride is converted to 3-azaisatoic anhydride: Synthesis, 972 (1982):
- For reviews, see: Chem. Soc. Rev., 7, 15 (1978); Synthesis, 861 (1980); Chem. Rev., 88, 351 (1988).
- Mitsunobu reaction, in the presence of DIAD, with 1,2- and 1,3-diols leads to regioselective, stereospecific azidation to give predominantly the 2- or 3-azido alcohol with inversion of configuration: J. Org. Chem., 64, 6049 (1999).
- Short: II/25C
- Non-explosive hydrazoic acid equivalent in many cycloaddition reactions: e.g. with alkynes to give 1,2,3-triazoles: Chem. Ber., 99, 2512 (1966), nitriles, catalyzed by Di-n-butyltin oxide, L14491, to give tetrazoles: J. Org. Chem., 58, 4139 (1993).
- A mild, convenient synthesis of alkyl azides involves SN2 reaction with the corresponding alkyl halide, phosphate or tosylate, promoted by TBAF: Synthesis, 376 (1995).
- In combination withSnCl4,ß-D-ribofuranosyl acetates are converted to azides: Carbohydr. Res., 232, 359 (1992). Similarly, reaction with tert-halides in the presence of tin(IV) chloride gives tert-azides, which can be converted to iminophosphoranes by Staudinger reduction with Triethyl phosphite, L00339. Hydrolysis completes a one-pot sequence for the conversion of a tert-halide to the corresponding amine: Synthesis, 487 (1987).
安全信息
GHS Symbol
- H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
- H301 Toxic if swallowed 吞食有毒
- H301+H311+H331
- H311 Toxic in contact with skin 皮肤接触中毒
- H331 Toxic if inhaled 吸入中毒
- H400 Verytoxictoaquaticlife 对水生生物毒性非常大。
- H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。
- P201 Obtain special instructions before use. 使用前获取专门指示。
- P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前,切勿操作。
- P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
- P233 Keep container tightly closed. ?保持容器密闭。
- P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
- P241 Use explosion-proof electrical/ventilating/lighting/…/equipment. 使用防爆电气/通风/照明/ .../设备。
- P241+P242+P243
- P242 Use only non-sparking tools. 只能使用无火花工具。
- P243 Take precautionary measures against static discharge. 采取预防措施,防止静电放电。
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
- P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
- P273 Avoid release to the environment. 避免释放到环境中。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P301+P310
- P301+P310+P330
- P301+P316
- P302+P352
- P302+P352+P312+P361+P364
- P303+P361+P353
- P304+P340
- P304+P340+P311
- P308+P313
- P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
- P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
- P316
- P321 Specific treatment (see … on this label). 具体治疗(见本标签上的)。
- P322 Specific measures (see …on this label). 具体治疗(见本标签上的)。
- P330 Rinse mouth. 漱口
- P361 Remove/Take off immediately all contaminated clothing. 立即去除/脱掉所有被污染的衣服。
- P361+P364
- P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
- P370+P378
- P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
- P403+P233
- P403+P235
- P405 Store locked up. 上锁保管。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- R11 Highly flammable 非常易燃
- R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入,皮肤接触及吞食都有毒
- R29 Contact with water liberates toxic gas. 遇水释放出有毒气体
- R50/53
- S16 Keep away from sources of ignition - No smoking 远离火源,禁止吸烟;
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
其他信息
- F:10-33
- 方法一:三甲基氯硅烷和迭氮化钠在六甲基亚磷酸三酰胺中反应而得。
- TCI Shanghai:叠氮三甲基硅 Trimethylsilylazide,>;96.0%(GC)(4648-54-8)
- 用途一:用作中间体
- 上游原料:叠氮化钠 --> 三甲基氯硅烷 --> 六甲基磷酰三胺 --> 亚磷酸三
- Sigma Aldrich:4648-54-8(sigmaaldrich)
- Acros Organics:叠氮三甲基硅烷 Azidotrimethylsilane, 97%(4648-54-8)
- 叠氮基三甲基硅烷价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 xw010180 叠氮化三甲基硅烷(TMSiA) 25g 500元 2011/04/16 T0801 叠氮三甲基硅 Trimethylsilylazide 25G 890元 2010/06/21 167930100 叠氮基三甲基硅烷 Azidotrimethylsilane 97% 10 ML 581元
- 用途三:有机合成试剂,向有机分子代入三甲硅基或叠氮基。
- MOL 文件:4648-54-8.mol
- 用途二:用于有机合成。
- 下游产品:2,2-二氯-1-甲基环丙胺
- Trimethylsilyl azide is a versatile azidonation reagent for amines, amides, aldehydes, and ketones.
- Alfa Aesar:叠氮化三甲基硅烷,94% Trimethylsilyl azide, 94%(4648-54-8)
- 海关编码:29310095
- 水中分解,溶于醚,二氯甲烷和苯。
- 敏感性:Moisture Sensitive
- MSDS 信息:Trimethylsilyl azide(4648-54-8).msds
- TSCA:Yes