Diphenyl diselenide 二苯基二硒醚
CAS 1666-13-3 MFCD00003001
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分类
- {SNA} Building Blocks, Chemical Synthesis, Organic Building Blocks, Selenium Compounds
- {uni_hamburg} no charge; carbocycle; aromatic; 6RingOnly; 6ring; 1fragment
产品应用
- 用于合成烯丙基醇、烯丙基醚、乙酸酯和α,β-不饱和羰基化合物。
相关文献及参考
- For introduction of the phenylseleno group by Michael addition, phenylselenol can be generated in situ by borohydride cleavage: Synthesis, 664 (1980).
- For a comprehensive review of the preparation of ɑß-unsaturated carbonyl compounds and nitriles by selenoxide elimination, see: Org. React., 44, 1 (1993). Compare also Phenylselenenyl bromide, A11906 and Phenylselenenyl chloride, A12751.
- Reagent for ɑ-phenylselenation of enolates. The products are readily oxidized to the selenoxides which undergo ambient temperature Cope-type elimination, providing a mild method for the introduction of ɑß-unsaturation into, e.g. ketones: J. Am. Chem. Soc., 97, 5434 (1975):
- Short: EINECS
- Short: III/5a
- Beilstein:6,346
- Oxidation of diphenyl diselenide by persulfate in the absence of a nucleophilic counter-ion generates the phenylselenium cation, which adds to alkenes. Molecules with a suitably placed nucleophilic site (alkene, hydroxyl, carbonyl, carboxyl, etc.) can then undergo intramolecular cyclization: J. Org. Chem., 55, 429 (1990); J. Chem. Soc. Perkin 1, 1989 (1993); Synlett, 373 (1994):
- Short: III/35G
- For reviews of the application of organoselenium reagents in organic synthesis, see: Tetrahedron, 34, 1049 (1978); Acc. Chem. Res., 12, 22 (1979); 17, 28 (1984). Monograph: Organoselenium Chemistry, D. Liotta, ed., Wiley, N.Y. (1987).
安全信息
GHS Symbol
- R33 Danger of cumulative effects 有累积作用的危险
- R50/53
- R23/25 Toxic by inhalation and if swallowed 吸入及吞食都有毒
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
- P301+P310
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- P273 Avoid release to the environment. 避免释放到环境中。
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
- P301+P310+P330
- P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
- P305+P351+P338
- P304+P340+P310
- P405 Store locked up. 上锁保管。
- P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
- P284 Wear respiratory protection.? 佩戴呼吸保护装置。
- P314 Get medical advice/attention if you feel unwell. 获取医疗咨询/就医,如果你觉得不舒服
- P403+P233
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
- H300+H330
- H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。
- H301+H331
- H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
- H331 Toxic if inhaled 吸入中毒
- H301 Toxic if swallowed 吞食有毒
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 28 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#05657
其他信息
- 职业标准:TLV-TWA 0.2 (硒) 毫克/ 立方米; STEL 0.3 (硒) 毫克/ 立方米
- TCI Shanghai:二苯基二硒醚 Diphenyl Diselenide,>;96.0%(GC)(1666-13-3)
- 二苯基二硒醚价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 XW16661331 二苯二硒醚 5g 216元 2011/08/23 XW16661332 二苯二硒醚 25g 659元 2011/08/23 XW16661333 二苯二硒醚 100g 1996元
- 外观性质:黄色固体, 无气味。
- 可燃性危险特性:明火可燃;高热分解有毒硒化物;与酸起作用
- 毒性分级:剧毒
- 方法一:溴苯和镁屑在绝对乙醚中制成苯基溴化镁,然后分批加入硒粉,使反应物维持激烈的回流状态。半小时后,加水破坏剩余的格氏试剂,冷却,搅拌下向混合物滴加溴,再慢慢加入氯化铵水溶液。过滤,滤饼用乙醚用乙醚洗涤。合并滤液和洗涤液,蒸除溶剂,使析出的固体溶于热己烷,滤去不溶物,滤液冷至6℃,过滤,干燥,得二硒二苯
- Acros Organics:二苯基联二硒 Diphenyl diselenide, 99%(1666-13-3)
- 急性毒性:静注- 小鼠 LD50: 28 毫克/ 公斤
- 溶于热醇、醚和二甲苯。不溶于水。
- MSDS 信息:二苯基二硒(1666-13-3).msds
- Sigma Aldrich:1666-13-3(sigmaaldrich)
- 储运特性:库房通风低温干燥; 与氧化剂、食品添加剂、酸类分开存放
- Alfa Aesar:二苯基二硒醚,98% Diphenyl diselenide, 98%(1666-13-3)
- 用途一:用于合成烯丙基醇、烯丙基醚、乙酸酯和α,β-不饱和羰基化合物。
- 灭火剂:泡沫、雾状水、砂土
- MOL 文件:1666-13-3.mol
- 上游原料:溴苯 --> 格氏试剂 --> 硒
- 类别:有毒物品