2,2,2-Trichloroethanol 2,2,2-三氯乙醇
CAS 115-20-8 MFCD00004677
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信息真实价格透明
资金保障
专业采购外包团队在线服务
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现货库存
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分类
- {uni_hamburg} no charge; alcohol; 1fragment
- {SNA} Alcohols, Building Blocks, C2 to C6, Chemical Synthesis, Organic Building Blocks, Oxygen Compounds
产品应用
- 用于有机合成、药物中间体。
相关文献及参考
- Reaction with POCl3 to give the phosphorodichloridate, followed by reaction with 3-Hydroxypropionitrile, L12570, gives 2-cyanoethyl 2,2,2-trichloroethyl phosphorochloridate, a valuable reagent, usually used without purification, for the phosphorylation of nucleosides: Synthesis, 831 (1980).
- Reaction with POCl3 to give the phosphorodichloridate, followed by reaction with 3-Hydroxypropionitrile, L12570, gives 2-cyanoethyl 2,2,2-trichloroethyl phosphorochloridate, a valuab
- Short: III/38B
- Short: EINECS
- Carboxyl groups can be protected as their trichloroethyl esters e.g. by tosic acid-catalyzed esterification: Synthesis, 24 (1979), or DCC-DMAP: J. Am. Chem. Soc., 111, 669 (1989). For esterification of amino acids, using the active ester with 2-Hydroxypyridine, A14522, see: Synthesis, 24 (1979). Cleavage occurs with Zn in AcOH or an aqueous THF buffer under mild conditions: J. Am. Chem. Soc., 88, 852 (1966); Synthesis, 457 (1976); or with NaBH4 in DMF, catalyzed by Se: Synthesis, 693 (1989). See also Appendix 6.
- Merck:14,9638 Beilstein:1,338
- Similarly, carbonyl compounds can be protected as their trichloroethyl acetals, stable to base, but readily cleaved under neutral aprotic conditions by Zn in ethyl acetate or THF: J. Org. Chem., 38, 554 (1973).
- Merck:14,9638
安全信息
GHS Symbol
- H336 May cause drowsiness or dizziness 肯能导致嗜睡或头晕
- H318 Causes serious eye damage 严重伤害眼睛
- H302 Harmful if swallowed 吞食有害
- P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P301+P330+P331
- P303+P361+P353+P310+P363
- P304+P340
- P304+P340+P310
- P305+P351+P338
- P305+P351+P338+P310
- P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
- P405 Store locked up. 上锁保管。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- R22 Harmful if swallowed 吞咽有害
- R41 Risk of serious damage to eyes 有严重损伤眼睛的危险
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
- S39 Wear eye/face protection 戴眼睛/面孔保护装置;
TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 500 mg/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - respiratory depression Lungs, Thorax, or Respiration - other changes REFERENCE : CRAAA7 Current Researches in Anesthesia and Analgesia. (Cleveland, OH) V.1-35, 1922-56. For publisher information, see AACRAT. Volume(issue)/page/year: 17,258,1938
TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Rectal SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 500 mg/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - respiratory depression Lungs, Thorax, or Respiration - other changes REFERENCE : CRAAA7 Current Researches in Anesthesia and Analgesia. (Cleveland, OH) V.1-35, 1922-56. For publisher information, see AACRAT. Volume(issue)/page/year: 17,258,1938
TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE
TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 50 mg/kg TOXIC EFFECTS : Behavioral - sleep REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 63,453,1938
TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 500 mg/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - respiratory depression Lungs, Thorax, or Respiration - other changes REFERENCE : CRAAA7 Current Researches in Anesthesia and Analgesia. (Cleveland, OH) V.1-35, 1922-56. For publisher information, see
TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Mold - Aspergillus nidulans DOSE/DURATION : 7750 ug/plate REFERENCE : CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year: 30,9,1980
TYPE OF TEST : Sister chromatid exchange TEST SYSTEM : Human Lymphocyte DOSE/DURATION : 178 gm/L REFERENCE : TOERD9 Toxicological European Research. (S.P.E., 10, Ave. de Messine, 75008 Paris, France) V.1- 1978- Volume(issue)/page/year: 3,63,1981
TYPE OF TEST : Sex chromosome loss and nondisjunction TEST SYSTEM : Mold - Aspergillus nidulans DOSE/DURATION : 10240 umol/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 155,105,1985
其他信息
- 无色液体。能与醇、醚混溶,溶于水,水溶液pH为5-6。易吸湿,有醚的气味。
- 蒸气压:1 mm Hg ( 20 °C)
- 毒性LD50(mg/kg):小鼠静脉注射LD50为201。
- 用途一:用作医药中间体
- 上游原料:三氯乙醛
- 蒸气密度:5.16 (vs air)
- 图谱信息:2,2,2-三氯乙醇(115-20-8)核磁图( 13 CNMR) 2,2,2-三氯乙醇(115-20-8)红外图谱(IR1) 2,2,2-三氯乙醇(115-20-8)质谱(MS) 2,2,2-三氯乙醇(115-20-8)核磁图( 1 HNMR) 2,2,2-三氯乙醇(115-20-8)Raman光谱
- 用途三:2,2,2-三氯乙醇(115-20-8)是苯甘头孢菌素的原料,羧(酸)基的保护基团。
- 方法一:由三氯乙醛还原而得。
- Acros Organics:2,2,2-三氯乙醇 2,2,2-Trichloroethanol, 99%(115-20-8)
- 外观形状:无色透明液体,菱形片状结晶(低温),或吸湿性液体。有醚样嗅味。
- Alfa Aesar:2,2,2-三氯乙醇,98% 2,2,2-Trichloroethanol, 99%(115-20-8)
- 用途二:用于有机合成、药物中间体。
- F:3-21
- 敏感性:Hygroscopic
- TCI Shanghai:2,2,2-三氯乙醇 2,2,2-Trichloroethanol,>;98.0%(GC)(115-20-8)
- 下游产品:氯甲酸-2,2,2-三氯乙酯 --> 对乙基苯甲酸 --> 3-甲基-8-氧代-7-(2-苯乙酰氨基)-5-硫杂-1-氮杂双环[4.2.0]辛-2-烯-乙羧酸-2,2,2-三氯乙酯
- MOL 文件:115-20-8.mol
- Sigma Aldrich:115-20-8(sigmaaldrich)
- 2,2,2-三氯乙醇价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 xw010350 2,2,2-三氯乙醇 100ml 400元 2011/04/16 T0622 2,2,2-三氯乙醇 2,2,2-Trichloroethanol 25G 196元 2011/04/16 T0622 2,2,2-三氯乙醇 2,2,2-Trichloroethanol 500G 1130元
- 海关编码:29055910
- MSDS 信息:Trichloroethanol(115-20-8).msds