o-Sulfobenzimide 糖精
CAS 81-07-2 MFCD00005866
信息真实价格透明
资金保障
专业采购外包团队在线服务
信息真实价格透明
资金保障
专业采购外包团队在线服务
品牌质保精细包装
现货库存
一流品牌服务
分类
- {SNA} Analytical Stan
- {SNA} Analytical Standards, Chromatography, EP Standards, EP Standards S - T, Pharmaceutical Standards, Pharmacopeia Standards, 分析/色谱
- Heterocycles
- {uni_hamburg} no charge; sulfur heterocycle; nitrogen heterocycle; carbocycle; aromatic; large ring; fused rings; 5ring; 6ring; 9ring; amide; lactame; 1fragment
- Sulfur & Selenium Compounds
- {SNA} Additional Standards, Analytical Standards,
- {SNA} Analytical Standards, Analytical/Chromatography, Melting Point Standards, Phy
- {SNA} Analytical Standards, Pharmacopeia Metrological Institutes Standards, USP Standards, USP Standards S - T, 分析/色谱
- {SNA} Analytical Standards, Analytical/Chromatography, Chromatography, Pharmaceutical Secondary Standards, Pharmaceutical Standards
- Pharmaceuticals
- {S
- Intermediates & Fine Chemicals
- {SNA} Analytical
- {SNA} Building Blocks,
产品应用
- Usually used in high performance liquid chromatographic method for the simultaneous separation and determination of acesulfame potassium, saccharine and aspartame;and also used in sweet preference test of rats.
相关文献及参考
- Arnold, D.L., et al.: Fundam. Appl. Toxicol., 4, 674 (1984),
- Short: IV/1a
- Taylor, J.D., et al.: Food Cosmet. Toxicol., 6, 313 (1968),
- Merck: 14,8311
- Short: III/5a
- Short: III/10a
- Short: IV/8A
- Merck: 14,8311 Beilstein:27(1)266
安全信息
- S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触;
- R63 Possible risk of harm to the unborn child 可能危害未出生婴儿
- R62 Possible risk of impaired fertility 有削弱生殖能力的危险
- R68 Possible risk of irreversible effects 可能有不可挽回的作用的危险
- R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Implant SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 80 mg/kg TOXIC EFFECTS : Tumorigenic - neoplastic by RTECS criteria Kidney, Ureter, Bladder - tumors REFERENCE : BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947- Volume(issue)/page/year: 11,212,1957
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 9600 mg/kg/10W-I TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors REFERENCE : BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947- Volume(issue)/page/year: 10,363,1956
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 548 gm/kg/1Y-C TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Endocrine - thyroid tumors REFERENCE : IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 24,197,1986
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 2008 gm/kg/2Y-C TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors REFERENCE : JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 40,583
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 17 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945- Volume(issue)/page/year: 35,1364,1979
TYPE OF TEST : Cytogenetic analysis ROUTE OF EXPOSURE : Oral TEST SYSTEM : Rodent - mouse DOSE/DURATION : 168 gm/kg/24W (Continuous) REFERENCE : IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hi
TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Salmonella typhimurium DOSE/DURATION : 2 mg/plate REFERENCE : SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year: 198,944,1977
TYPE OF TEST : Unscheduled DNA synthesis TEST SYSTEM : Rodent - rat Liver DOSE/DURATION : 100 pmol/L REFERENCE : CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 5,1547,1984
TYPE OF TEST : DNA damage TEST SYSTEM : Rodent - rat Liver DOSE/DURATION : 3 mmol/L REFERENCE : SinJF# Personal Communication from J.F. Sina, Merck Institute for Therapeutic Research, West Point, PA 19486, Oct. 26, 1982 Volume(issue)/page/year: 26OCT1982
TYPE OF TEST : DNA inhibition TEST SYSTEM : Rodent - rat Cells - not otherwise specified DOSE/DURATION : 1 mmol/L REFERENCE : ICDBEO In Vitro Cellular and Developmental Biology. (Tissue Culture Assoc., 19110 Montgomery Village Ave., Suite 300, Gaithersburg, MD 20879) V.21- 1985- Volume(issue)/page/year: 21,402,1985
TYPE OF TEST : Sister chromatid exchange TEST SYSTEM : Rodent - hamster Lung DOSE/DURATION : 100 mg/L REFERENCE : BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947- Volume(is
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE : 252 gm/kg SEX/DURATION : multigenerations TOXIC
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE : 16800 mg/kg SEX/DURATION : multigenerations TOXIC EFFECTS : Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) REFERENCE : TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 8,285,1977
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE : 155 mg/kg SEX/DURATION : female 7 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetal death REFERENCE : IIZAAX Iwate Igaku Zasshi. Journal of the Iwate Medical Association. (c/o Iwate Ika Daigaku, 19-1 Uchimaru, Morioka, 020, Japan) V.1- 1947- Volume(issue)/page/year: 16,330,1964
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE : 252 gm/kg SEX/DURATION : multigenerations TOXIC EFFECTS : Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4) REFERENCE : DBTEAD Diabete. (Le Raincy, France) V.1-22, 1953-74. Discontinued. Volume(issue)/page/year: 17,103,1969
GHS Symbol
- P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛,皮肤或衣服。
- P281 Use personal protective equipment as required. 使用所需的个人防护装备。
- P305+P351+P338
其他信息
- 下游产品:3-(4-甲氧基-6-甲基-1
- MOL 文件:81-07-2.mol
- 图谱信息:糖精(81-07-2)质谱(MS) 糖精(81-07-2)红外图谱(IR2) 糖精(81-07-2)红外图谱(IR1) 糖精(81-07-2)核磁图( 1 HNMR)
- Sigma Aldrich:81-07
- 参考质量标准:FAO/WHO,1992 含量(干基计)/% 99~101 干燥失重(105℃,2h) ≤1% 熔程/℃ 226~230 苯甲酸和水杨酸试验 阴性 易碳化物试验 正常 硫酸盐灰分(GT-5) ≤0.2% 甲苯磺酰胺
- {Chemical
- 上游原料:亚硝酸钠 --> 氨 --> 次氯酸钠 --> 硫酸铜 --> 氨茴酸甲酯 --> 2-(氯磺酰基)苯甲酸甲酯 --> 邻氨基联苯 --> 碘化钾淀粉试纸 --> 墨绿 --> 氯苯甲酸
- 糖精价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 B0004 邻磺酰苯甲酰亚胺 o-Sulfobenzimide 500G 537元 2014/06/02 B0004 邻磺酰苯甲酰亚胺 o-Sulfobenzimide 25G 123元 2010/06/21 149001000 糖精 Saccharin 98+% 100 GR 267元
- 毒性分级:低毒
- TCI Shanghai:邻磺酰苯甲酰亚胺 o-Sulfobenzimide,>;99.0%(LC)(T)(81-07-2)
- Acros Organics:糖精/邻磺酰苯甲酰亚胺 Saccharin, 98+%(81-07-2)
- 含量分析:精确称取预经干燥的试样0.5g,溶于75ml热水。迅速冷却,加酚酞试液(TS-167)数滴,用0.1mol/L氢氧化钠滴定。每Ml0.1mol/L氢氧化钠相当于糖精(C7H5NO3S)18.32mg。
- {Ch
- 灭火剂:干粉,泡沫,沙土,二氧化碳, 雾状水
- 类别:有毒物品
- 用途四:磷酸转
- 使用限量:FDA,§180.37(2000):饮料、果汁、固体饮料,12mg/28.4lml液体,甜度相当于一汤匙的量为20mg;每一份规定大小的加工食品为30mg。 USDA,9CFR,§318.7(2000):扎肉(培根)0.01%。
- 方法二:其制备方法是由苯酐经胺化降解、重氮化、置换、氧化、酸析等步骤而得。将苯酐加入反应锅,加入0℃的氢氧化铵溶液,升温至50℃,加入氢氧化钠溶液,控制加碱速度,使温度保持在70℃以下,pH值保持在8.5~8.9。加碱结束,将pH值调节至12~13,在65~70℃保温0.5h,保温赶氨气35h,冷至-10℃,加入已预冷的-10℃的甲醇和-10℃的次氯酸钠溶液,在0℃以下反应45min,再逐渐升温至30℃,以碘化钾淀粉试纸测试应呈无色反应,然后加入适量亚硫酸氢钠水解。料液转稀后,加热至50℃,再加入80℃热水,搅拌溶解,静置后过滤,分取油层,得邻氨基苯甲酸甲酯。 将邻氨基苯甲酸甲酯和亚硝酸钠溶液搅拌混匀,滴加到重氮锅内的混酸中反应,开始滴加的温度10℃左右,反应温度不超过25℃,反应终点碘化钾淀粉液呈淡绿色。将此重氮反应液冷至10℃,加入硫酸铜溶解后通入SO 2 (约1h通完),析出邻亚磺酸苯甲酸甲酯,用H酸试纸测试置换终点应显无色,
- 方法三:由苯酐经胺化、降解、酯化、重氮化、置换、氯化、环合、酸析等步骤而得。(1)胺化、降解、酯化制备邻氨基苯甲酸甲酯。(2)重氮化、置换、氯化得邻磺氯苯甲酸甲酯。(3)环合、酸析得到不溶性糖精。
- 毒性:ADI 0~5(ADI指糖精及其钙、钾、钠盐之和;FAO/WHO,2001)。 LD 50 14200mg/kg(大鼠,经口)。
- {C
- MSDS 信息:1,2-Benzisothiazol-3
- 所属类别二:食品添加剂: 调味剂(风味增强剂): 甜味剂
- 所属类别一:农药中间体: 杀菌剂中间体: 其他类杀菌剂
- 所属类别二:食品添加