CAS 79-14-1 MFCD00004312-Glycolic Acid 羟基乙酸 TAO{mole}

Glycolic Acid 羟基乙酸

CAS 79-14-1 MFCD00004312

化学结构图

SMILES: O=C(O)CO

化学属性

Mol. Formula	C2H4O3
Mol. Weight	76.05
Density	1.25 g/mL at 25 °C
Refractive index	n20/D 1.412
Flash Point	None
TSCA	Yes
Boiling Point	112 °C at 760 mmHg
Melting Point	75-80°C
Solubility	可溶
Stability	对湿度敏感
pH	:A

别名和识别编码

Chemical Name	Glycolic Acid
CAS Number	79-14-1
Synonym	Glycolic acid {LY} Glycolic acid {} {LY} Glycolic acid {} {} {LY} Glycolic acid {} {} {} {LY} Glycolic acid {} {} {} {} {LY} Glycolic acid {} {} {} {} {} {LY} Glycolic acid {} {} {} {} {} {} {LY} Glycolic acid {} {} {} {} {} {} {} {LY} Glycolic acid {} {} {} {} {} {} {} {} {LY} Glycolic acid {} {} {} {} {} {} {} {} {} {LY} Glycolic acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Glycolic acid {} {} {} {} {} {} {} {} {} {} {} {LY} Glycolic acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Glycolic acid {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Glycolic acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Glycolic acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Glycolic acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Glycolic acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
MDL Number	MFCD00004312
EC Number	201-180-5
Beilstein Registry Number	1209322
Merck Number	4498
PubChem Substance ID	87570382
Reaxys-RN	1209322
Chemical Name Translation	羟基乙酸
Wiswesser Line Notation	QV1Q
LabNetwork Molecule ID	LN00193631
InChI	InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)
Canonical SMILES	O=C(O)CO

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产品应用

分析试剂，pH的控制，有机合成，薄荷脑和奎宁酯类的制备，染发剂配制。

安全信息

Signal word Danger

GHS Symbol

WGK Germany1

Safety Statements

S20 When using do not eat or drink 使用时，不得进食，饮水；
S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾；
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
S9 Keep container in a well-ventilated place 保持容器在通风良好的场所；

Risk Statements

R20 Harmful by inhalation 吸入有害
R22 Harmful if swallowed 吞咽有害
R34 Causes burns 会导致灼伤

Precautionary statements

P201 Obtain special instructions before use. 使用前获取专门指示。
P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
P273 Avoid release to the environment. 避免释放到环境中。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P301+P330+P331+P310
P303+P361+P353
P303+P361+P353+P310+P363
P304+P340+P310
P305+P351+P338
P305+P351+P338+P310
P308+P311
P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
P405 Store locked up. 上锁保管。
P501 Dispose of contents/container to..… 处理内容物/容器.....

RTECSMC5250000

Packing GroupII

UN Number 3261

Storage condition 2-8°C {LY} 2-8°C Hygroscopic {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {

Hazard statements

H290 May be corrosive to metals 可能腐蚀金属。
H302 Harmful if swallowed 吞食有害
H302+H332
H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
H332 Harmful if inhaled 吸入有害

Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

Hazard Codes 8 C

Hazard Class8

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1950 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Gastrointestinal - other changes
   Kidney, Ureter, Bladder - other changes
REFERENCE :
   JIHTAB Journal of Industrial Hygiene and Toxicology.  (Cambridge, MA)
   V.18-31, 1936-49.  For publisher information, see AEHLAU.
   Volume(issue)/page/year: 23,259,1941

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
   Prague, Czechoslovakia, Avicenum, 1986  Volume(issue)/page/year: -,656,1986

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 1920 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Gastrointestinal - other changes
   Kidney, Ureter, Bladder - other changes
REFERENCE :
   JIHTAB Journal of Industrial Hygiene and Toxicology.  (Cambridge, MA)
   V.18-31, 1936-49.  For publisher information, see AEHLAU.
   Volume(issue)/page/year: 23,259,1941

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 9 gm/kg
SEX/DURATION            : female 7-12 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Maternal Effects - other effects
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 53,117,1996

其他信息

用途四:分析试剂，pH的控制，有机合成，薄荷脑和奎宁酯类的制备，染发剂配制。
Acros Organics:A-羟基乙酸/乙醇酸 Glycolic acid, 99%(79-14-1)
方法一:1.氯乙酸法氯乙酸在碱性条件下水解得粗品，然后经甲醇酯化得羟基乙酸甲酯，蒸馏后再水解即得成品。2.高温高压法由甲醛、二氧化碳和水反应制得。3.氰化水解法由甲醛和氢氰酸为原料，经加氰合成和酸性水解制得。4.氰化钠法以甲醛、氰化钠为原料，经加氰和酸性水解两步制得。
乙醇酸价格(试剂级):更新日期产品编号产品名称包装价格 2011/08/23 30093924 甘醇酸 25g 10.8元 2011/08/23 S12473701 乙醇酸 25g 427元 2011/04/16 G0110 乙醇酸(约70%的水溶液,约12mol/L) Glycolic Acid (ca. 70% in Water, ca. 12mol/L) 25G 146元
TCI Shanghai:羟基乙酸(约70%的水溶液,约12mol/L) Glycolic Acid (ca. 70% in Water, ca. 12mol/L)(79-14-1)
MSDS 信息:羟基乙酸(79-14-1).msds
上游原料:氢氧化钠 --> 二氧化碳 --> 氰化钠 --> 氢氰酸 --> 羟乙酸甲酯
略吸湿，能溶于水、甲醇、乙醇、丙酮、乙酸和醚。对皮肤和粘膜略有刺激性，水溶液的pH：2.5(0.5%)、2.33(1.0%)、2.16(2.0%)、1.91(5.0%)、1.73(10.0%)。低毒，半数致死量(大鼠，经口)1950mg/kg。有腐蚀性。
用途二:用作制革助剂、水消毒剂、牛奶棚消毒剂、锅炉除垢剂等
用途一:用于有机合成,日化添加剂替代果酸
用途三:有机合成的原料，可用于生产乙二醇。羟基乙酸主要用作清洗剂。2%的羟基乙酸和1%的甲酸混合配成的混合酸，是一种效率高成本低的洗涤剂，适合于清洗空调机；可制取纤维染色剂、清净剂、焊接剂的配料、清漆配料、铜蚀剂、粘合剂、石油破乳剂和金属螯合剂等；羟基乙酸的钠盐、钾盐用作电镀液添加剂。其他的用途还有电解研磨、金属酸洗、皮革染色和鞣革剂等。也可用作化学分析试剂。
敏感性:Hygroscopic
下游产品:氯乙酸 --> 乙二胺四乙酸 --> 阿西美辛 --> 苯噻草胺 --> 苯并咪唑-2-甲酰氯盐酸盐 --> 聚乙醇酸(PGA)及共聚物 --> 羟乙酸甲酯 --> 3-吲哚乙酸 --> 乙酰氧基乙酰氯 --> 1H-苯并咪唑-2-甲酸 --> 2-羟甲基苯并咪唑
MOL 文件:79-14-1.mol
Alfa Aesar:羟基乙酸,大约为67%的水溶液 Glycolic acid, ca 67% aq. soln.(79-14-1)
外观性质:无色易潮解的晶体, 70%的工业品是一种淡黄色液体。
Sigma Aldrich:79-14-1(sigmaaldrich)
图谱信息:乙醇酸(79-14-1)Raman光谱乙醇酸(79-14-1)核磁图( 1 HNMR) 乙醇酸(79-14-1)核磁图( 13 CNMR) 乙醇酸(79-14-1)红外图谱(IR1) 乙醇酸(79-14-1)红外图谱(IR2) 乙醇酸(79-14-1)质谱(MS)