1,4-Diazabicyclo[2.2.2]octane 三乙烯二胺
CAS 280-57-9 MFCD00006689
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分类
- {SNA} Acids & Bases, Amine Monomers, Bases, Chemical Biology, Chemical Synthesis, Conjugation Chemistry: Azides, Alkynes and Other Reagents, Materials Science, Monomers, Organic Bases, Polymer Science, Staudinger Ligation, Synthetic Reagents, Tertiary Amines
- {SNA} Acids & Bases, Amine Monomers, Bases, Chemical Biology, Chemical Synthesis, Conjugation Chemistry: Azides, Alkynes and Other Reagents, Monomers, Organic Bases, Polymer Science, Staudinger Ligation, Synthetic Reagents, Tertiary Amines,
- {SNA} Acids & Bases,
产品应用
- An anti-fade reagent shown to scavenge free-radicals due to flurochrome excitation.
相关文献及参考
- Short: II/25D
- Merck: 14,9669
- Merck: 14,9669 Beilstein: 23,V,3,487
- In conjunction with palladium acetate and PEG-400 provides a reusable catalyst system for the Suzuki-Miyaura cross-coupling reaction of boronic acids: J. Org. Chem., 70, 5409 (2005).
- Forms a stable crystalline complex with H2O2, useful as an equivalent to "anhydrous" H2O2: reaction with TMS chloride gives bis(TMS) peroxide, a useful OH+-equivalent, e.g. in the conversion of aryllithiums to phenols: Synthesis, 633 (1986).
- Forms crystalline complexes with organolithium compounds: J. Am. Chem. Soc., 87, 3276 (1965), which show enhanced reactivity, e.g. in the high yield ɑ-metallation of thioanisole by n-BuLi: J. Org. Chem., 31, 4097 (1966).
- Dabco is a registered trademark of Air Products and Chemicals Inc.
- For further illustrative example, see: Org. Synth., 75, 106 (1997). Complete reaction often takes several days at ambient temperature, while heating causes lower yields. However, it is greatly accelerated by microwave irradiation: Synlett, 444 (1994). Superior results with reduced reaction times can be achieved in aqueous medium: J. Org. Chem., 66, 5413 (2001). The use as reaction medium of tetramethylene sulfone: Tetrahedron Lett., 45, 1183 (2004), or PEG-400: Tetrahedron Lett., 45, 5865 (2004) has also been advocated. Lithium perchlorate was found to increase the reaction rate dramatically: Tetrahedron Lett., 40, 1539 (1999), as was a catalytic amount of a metal triflate, particularly La or Sm; conventional Lewis acids were ineffective: J. Org Chem., 63, 7183 (1998). For asymmetric Baylis-Hillman reaction using (1S,2R)-(-)-10,2-Camphorsultam, A15897, as chiral auxiliary, see: J. Am. Chem. Soc., 119. 4317 (1997). See also 3-Quinuclidinol, B21503. For more recent discussion and comparison of different catalysts, see: J. Org. Chem., 692 (2003). In a reinterpretaion of the mechanism, a hemiacetal interemediate has been proposed: J.
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安全信息
GHS Symbol
- S16 Keep away from sources of ignition - No smoking 远离火源,禁止吸烟;
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
- S3 Keep in a cool place 保存在阴凉处;
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
- S37/39 Wear suitable gloves and eye/face protection 穿戴适当的手套和眼睛/面保护;
- S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置;
- S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中,参考特别指示/安全收据说明书;
- R11 Highly flammable 非常易燃
- R22 Harmful if swallowed 吞咽有害
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
- R52/53
- P201 Obtain special instructions before use. 使用前获取专门指示。
- P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前,切勿操作。
- P203
- P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
- P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
- P241 Use explosion-proof electrical/ventilating/lighting/…/equipment. 使用防爆电气/通风/照明/ .../设备。
- P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P264+P265
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
- P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
- P273 Avoid release to the environment. 避免释放到环境中。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P281 Use personal protective equipment as required. 使用所需的个人防护装备。
- P301+P312
- P301+P317
- P301+P330+P331+P310
- P302+P352
- P303+P361+P353+P310+P363
- P304+P340
- P304+P340+P310
- P305+P351+P338
- P305+P351+P338+P310
- P305+P354+P338
- P308+P313
- P308+P316
- P309+P311
- P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
- P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
- P314 Get medical advice/attention if you feel unwell. 获取医疗咨询/就医,如果你觉得不舒服
- P317
- P318
- P319
- P321 Specific treatment (see … on this label). 具体治疗(见本标签上的)。
- P330 Rinse mouth. 漱口
- P332+P313
- P332+P317
- P337+P313
- P337+P317
- P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
- P362+P364
- P370+P378
- P403+P233
- P405 Store locked up. 上锁保管。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- H228 Flammable solid 易燃固体
- H302 Harmful if swallowed 吞食有害
- H315 Causes skin irritation 会刺激皮肤
- H318 Causes serious eye damage 严重伤害眼睛
- H319 Causes serious eye irritation 严重刺激眼睛
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- H412 Harmfutoaquaticlifewithlonglastingeffects 对水生生物有害并具有长期影响。
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 2250 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Behavioral - muscle contraction or spasticity REFERENCE : GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 45(5),67,1980
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1700 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ZHYGAM Zeitschrift fuer die Gesamte Hygiene und Ihre Grenzgebiete. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1955- Volume(issue)/page/year: 20,393,1974
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 1100 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Behavioral - muscle contraction or spasticity REFERENCE : GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 45(5),67,1980
其他信息
- 易溶于水,水中溶解度: 46 g/100ml (26 C), 溶于丙酮、苯及乙醇等常规有机溶剂,溶于戊烷、已烷、庚烷等直链烃类;暴露在空气中易吸湿潮解并结块,能吸收空气中的CO2 并发黄。
- 用途三:主要用作聚氨酯发泡(硬泡、软泡)催化剂。可以直接使用,也可以配成A―33后使用。还有用作农药生产的引发剂(如六氨吡啶的引发剂),以及无氰电镀添加剂。该产品呈强碱性、低毒,有刺激性,使用时应穿戴防护用品。
- 方法一:将1,2-二氯乙烷和氨水送入管式反应器中,于150-250℃、392kPa压力下进和热压氨化反应。反应液以碱中和得到混合游离胺,经浓缩除去氯化钠,然后将粗吕减压蒸馏,收集不同馏分进行分离。在获得该品同时,并联产乙二胺、二亚乙基三胺、三亚乙基四胺、四亚乙基五胺和多亚乙基多胺。从生产六水哌嗪的母液中经分馏可得该品,第生产100t六水哌嗪可得六水三亚乙基二胺约3-4t。
- 三乙烯二胺价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 30184062 三乙烯二胺 250g 79.6元 2011/04/16 D0134 1,4-二氮杂二环[2.2.2]辛烷 1,4-Diazabicyclo[2.2.2]octane 25G 190元 2011/04/16 D0134 1,4-二氮杂二环[2.2.2]辛烷 1,4-Diazabicyclo[2.2.2]octane 500G 1320元
- MSDS 信息:1,4-Diazabicyclo[2.2.2]octane(280-57-9).msds
- TCI Shanghai:1,4-二氮杂二环[2.2.2]辛烷 1,4-Diazabicyclo[2.2.2]octane,>;98.0%(T)(280-57-9)
- MOL 文件:280-57-9.mol
- 上游原料:乙二胺 --> 氯乙烷 --> 二乙烯三胺 --> 哌嗪(六水) --> 三乙烯四胺 --> 多乙烯多胺 --> 四亚乙基五胺
- 用途二:用于制取聚氨酯类泡沫塑料的催化剂和石油添加剂。
- Alfa Aesar:1,4-二偶氮双环[2.2.2]辛烷,98% 1,4-Diazabicyclo[2.2.2]octane, 98%(280-57-9)
- 下游产品:双二苯基磷酰联萘 --> 5-溴嘧啶-2-羧酸 --> 苯磺隆 --> 1,1'-联萘-2,2'-双二苯膦 --> 双二苯基磷酰联萘 --> 脱氢乙酸 --> S-(-)-1,1'-联萘-2,2'-双二苯膦 --> R-(+)-1,1'-联萘-2,2'-双二苯膦 --> 2-溴甲基丙烯酸乙酯 --> 2-氯-3-氟异烟酸 --> 3-氟吡啶-2-羧酸 --> 5-溴-2-氰基嘧啶
- Sigma Aldrich:280-57-9(sigmaaldrich)
- 蒸气压:2.9 mm Hg ( 50 °C)
- F:3
- Acros Organics:1,4-二叠氮双环[2.2.2]辛烷/三乙烯二胺 1,4-Diazabicyclo[2.2.2]octane, 97%(280-57-9)
- 用途一:可用于聚氨酯泡沫体、弹性体及涂料等多种制品的生产
- 海关编码:29335920
- 敏感性:Hygroscopic