CAS 118-48-9 MFCD00006700-Isatoic anhydride 靛红酸酐 TAO{mole}

Isatoic anhydride 靛红酸酐

CAS 118-48-9 MFCD00006700

化学结构图

SMILES: O=c1[nH]c2ccccc2c(=O)o1

化学属性

Mol. Formula	C8H5NO3
Mol. Weight	163.13
Density	1.520
Vapor Density	5.6 (vs air)
Melting Point	233°C
Flash Point	308°C
TSCA	Yes
Solubility	分解
Boiling Point	290.19 °C at 760 mmHg

别名和识别编码

Chemical Name	Isatoic anhydride
CAS Number	118-48-9
Synonym	Isatoic anhydride {LY} Isatoic anhydride {} {LY} Isatoic anhydride {} {} {LY} Isatoic anhydride {} {} {} {LY} Isatoic anhydride {} {} {} {} {LY} Isatoic anhydride {} {} {} {} {} {LY} Isatoic anhydride {} {} {} {} {} {} { {} {} {} {} {} {} {LY} Isatoic anhydride {} {} {} {} {} {} {} {LY} Isatoic anhydride {} {} {} {} {} {} {} {} {LY} Isatoic anhydride {} {} {} {} {} {} {} {} {} {LY} Isatoic anhydride {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Isatoic anhydride {} {} {} {} {} {} {} {} {} {} {} {LY} Isatoic anhydride {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Isatoic anhydride {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Isatoic anhydride {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Isatoic anhydride {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Isatoic anhydride {} {} {}
EC Number	204-255-0
Beilstein Registry Number	136786
MDL Number	MFCD00006700
PubChem Substance ID	8359
Reaxys-RN	136786
Chemical Name Translation	靛红酸酐
Wiswesser Line Notation	T66 BMVOVJ
LabNetwork Molecule ID	LN00239602
InChI	InChI=1S/C8H5NO3/c10-7-5-3-1-2-4-6(5)9-8(11)12-7/h1-4H,(H,9,11)
Canonical SMILES	O=C1OC(C2=C(N1)C=CC=C2)=O

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产品应用

Isatoic anhydride is a potent inactivator of ?-chymotrypsin and inactivates stoichiometrically. Isatoic Anhydride is an important compound in the preparation of serine protease inhibitors.

安全信息

Signal word

GHS Symbol

WGK Germany1

Safety Statements

Risk Statements

R36 Irritating to eyes 刺激眼睛
R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应

Precautionary statements

P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P302+P350
P302+P352
P302+P352+P333+P313+P362+P364
P305+P351+P338
P305+P351+P338+P337+P313
P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
P333+P313
P337+P313
P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
P501 Dispose of contents/container to..… 处理内容物/容器.....

Hazard statements

H317 May cause an allergic skin reaction 可能导致皮肤过敏
H319 Causes serious eye irritation 严重刺激眼睛

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves

RTECSDM3100000

Storage condition Store at room temperature {LY} Store at room temperature {} {LY} Store at room temperature {} {} {LY} Store at room temperature {} {} {} {LY} Store at room temperature {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {}

Hazard Codes Xi

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 34800 mg/kg
SEX/DURATION            : male 8 day(s) pre-mating
                          female 21 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - female fertility index (e.g. # females pregnant
   per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
   MPHEAE Medicina et Pharmacologia Experimentalis.  (Basel, Switzerland)
   V.12-17, 1965-67.  For publisher information, see PHMGBN.
   Volume(issue)/page/year: 15,7,1966

其他信息

靛红酸酐价格(试剂级):更新日期产品编号产品名称包装价格 2011/04/16 I0081 靛红酸酐 Isatoic Anhydride 500G 1620元 2011/04/16 I0081 靛红酸酐 Isatoic Anhydride 25G 233元 2010/06/21 122481000 靛红酸酐 Isatoic anhydride 98% 100 GR 226元
TCI Shanghai:靛红酸酐 Isatoic Anhydride,>;99.0%(T)(118-48-9)
MSDS 信息:4H-3,1-Benzoxazine-2,4(1H)-dione(118-48-9).msds
Sigma Aldrich:118-48-9(sigmaaldrich)
方法一:由邻氨基苯甲酸与光气反应而得。将邻氨基苯甲酸溶解于热水和浓盐酸中，在搅拌下通入光气，靛红酸酐立即析出。反应放热，调节光气通入速度，使温度不超过50℃。连续通入光气2-4h，至吸收速度显著减慢为止。将产物在空气中晾干，于100℃干燥即得成品。
图谱信息:靛红酸酐(118-48-9)质谱(MS) 靛红酸酐(118-48-9)核磁图( 1 HNMR) 靛红酸酐(118-48-9)红外图谱(IR2) 靛红酸酐(118-48-9)红外图谱(IR1)
Acros Organics:靛红酸酐 Isatoic anhydride, 98%(118-48-9)
F:3
外观:浅黄色粉末或灰白色结晶
上游原料:邻氨基苯甲酸
用途二:用于有机合成。
用途一:用作医药、农药、染料的原料，是除草剂苯达松的重要中间体
企业检测数据参考:氯化物：0.001 % 干燥失重：0.001 % 相关物质：0.001 % 重金属：0.001 ppm
靛红酸酐价格(试剂级):更新日期产品编号产品名称包装价格 2014/06/02 I0081 靛红酸酐 Isatoic Anhydride 500G 1540元 2014/06/02 I0081 靛红酸酐 Isatoic Anhydride 25G 234元 2010/06/21 122481000 靛红酸酐 Isatoic anhydride 98% 100 GR 226元
MOL 文件:118-48-9.mol
淀粉邻氨基苯甲酸酯:淀粉邻氨基苯甲酸酯(Starch anthranilate)在造纸工业中可提高无机填料和细小纤维的留着率，也能提高干强度和抗张强度。在多种溶剂及各种不同催化剂存在时，淀粉邻氨基苯甲酸酯是由淀粉与靛红酸酐反应制得。经典方法是以三乙胺作催化剂，在二甲基亚砜溶剂中反应。 (1) 将40g淀粉 (在100℃干燥过夜)，4.0g靛红酸酐，5ml三乙胺，在500ml二甲基亚砜中，90～95℃搅拌反应3h，在室温下放置过夜后，将所得浅棕色液体倒入1L甲醇，沉淀用甲醇洗，晾干，得白色粉末状样品。含氮0.75%，取代度为0.093。 (2)在水溶液中反应。将90g玉米淀粉分散在250ml水中，在30分钟内加入8g靛红酸酐，并用6%氢氧化钠溶液将pH调至8.5～9.0，在2小时反应时间内保持此pH值。反应结束后过滤，用2L水洗，晾干后置于索氏提取器中，用乙醇连续提取24h。所得产物含0.70%氮，口香糖基料可用取代度(DS)为0.086。
产品类别:靛红系列
敏感性:Moisture Sensitive
Alfa Aesar:靛红酸酐,97% Isatoic anhydride, 97%(118-48-9)
海关编码:29349990
蒸气密度:5.6 (vs air)